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Year : 2014  |  Volume : 32  |  Issue : 3  |  Page : 304-309

Clinical and microbiological characteristics of Rhodotorula mucilaginosa infections in a tertiary-Care facility


1 Department of Microbiology, Vardhman Mahaveer Medical College and Safdarjung Hospital, New Delhi, India
2 Department of Neurology, Vardhman Mahaveer Medical College and Safdarjung Hospital, New Delhi, India
3 Department of Hematology, Vardhman Mahaveer Medical College and Safdarjung Hospital, New Delhi, India

Correspondence Address:
M R Capoor
Department of Microbiology, Vardhman Mahaveer Medical College and Safdarjung Hospital, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0255-0857.136576

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Background: Rhodotorula spp. are an emergent opportunistic pathogen, particularly in immunocompromised individuals. Materials and Methods: The aim of the study was to review reported cases of Rhodotorula infection over a period of 9 years to determine epidemiology, risk factors, treatment and outcome. Results: The Rhodotorula spp. were isolated from cerebrospinal fluid (9) and blood (5). The most common pre-disposing factors were prolonged hospital stay (>1 month) and prolonged usage of broad-spectrum antibiotics (>1 month). All the isolates were identified as R. mucilaginosa by conventional methods. Amphotericin B demonstrated lowest minimum inhibitory concentration (MIC) as compared with other anti-fungal agents (fluconazole, itraconazole and voriconazole). Conclusions: The recognition of unusual yeasts as an agent of life-threatening infection and their intrinsic resistance increases the burden on the mycology laboratory for complete species identification and to determine minimum inhibitory concentration.






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