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 REVIEW ARTICLE
Year : 2014  |  Volume : 32  |  Issue : 2  |  Page : 112-123

Revamping the role of biofilm regulating operons in device-associated Staphylococci and Pseudomonas aeruginosa


1 Department of Studies in Microbiology, University of Mysore, Mysore, Karnataka, India
2 Department of Microbiology, JSS Medical College, Sri Shivarathreeshwara Nagara, Mysore, Karnataka, India

Correspondence Address:
Shubha Gopal
Department of Studies in Microbiology, University of Mysore, Mysore, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0255-0857.129766

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Extensive use of indwelling devices in modern medicine has revoked higher incidence of device associated infections and most of these devices provide an ideal surface for microbial attachment to form strong biofilms. These obnoxious biofilms are responsible for persistent infections, longer hospitalization and high mortality rate. Gene regulations in bacteria play a significant role in survival, colonization and pathogenesis. Operons being a part of gene regulatory network favour cell colonization and biofilm formation in various pathogens. This review explains the functional role of various operons in biofilm expression and regulation observed in device-associated pathogens such as Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa.






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2004 - Indian Journal of Medical Microbiology
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