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 ORIGINAL ARTICLE
Year : 2014  |  Volume : 32  |  Issue : 1  |  Page : 49-52

Prevalence of inducible clindamycin resistance among community-associated staphylococcal isolates in central Serbia


1 Department of Microbiology, Institute of Medical Microbiology and Immunology, University of Pristina, Kosovska Mitrovica, Serbia
2 Public Health Institute Vranje, Serbia
3 Public Health Institute, Kragujevac, Serbia
4 Institute of Medical Statistics and Informatics, University of Belgrade, Serbia
5 Veterinary Specialized Institute Kraljevo, Kraljevo, Serbia
6 Public Health Institute, Kragujevac; Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, Kragujevac, Serbia

Correspondence Address:
B D Dejan
Public Health Institute, Kragujevac; Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, Kragujevac
Serbia
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Source of Support: This research was supported by the Serbian Ministry of Education and Science, project III 41010-2,, Conflict of Interest: None


DOI: 10.4103/0255-0857.124304

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The emergence of resistance to most antimicrobial agents in staphylococci indicates the need for new effective agents in the treatment of staphylococcal infections. Clindamycin is considered to be one safe, effective and less costly agent. We analysed 482 staphylococcal isolates. Detection of inducible clindamycin resistance was performed by the D-test, while the presence of methylases genes: erm (A), erm (B) and erm (C), as well as, macrolide efflux gene mef was determined by polymerase chain reaction. Inducible clindamycin resistance phenotype was significantly higher in Staphylococcus aureus (S. aureus) strains then in coagulase-negative staphylococci (CNS). Among analysed S. aureus isolates, the predominance of the erm (C) gene, followed by the erm (A) gene were detected. These results indicate that the D-test should be routinely performed on each staphylococcal isolates.






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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04