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  Table of Contents  
CORRESPONDENCE
Year : 2013  |  Volume : 31  |  Issue : 2  |  Page : 204
 

A novel pathogen for gastroenteritis: Laribacter hongkongensis


1 Centre for Infectious Diseases and Control, School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu, India
2 Bioinformatics Division, School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu, India

Date of Submission29-Apr-2013
Date of Acceptance30-Apr-2013
Date of Web Publication19-Jul-2013

Correspondence Address:
A R Ghosh
Centre for Infectious Diseases and Control, School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0255-0857.115240

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How to cite this article:
Raja M K, Lulu S S, Ghosh A R. A novel pathogen for gastroenteritis: Laribacter hongkongensis. Indian J Med Microbiol 2013;31:204

How to cite this URL:
Raja M K, Lulu S S, Ghosh A R. A novel pathogen for gastroenteritis: Laribacter hongkongensis. Indian J Med Microbiol [serial online] 2013 [cited 2019 Nov 13];31:204. Available from: http://www.ijmm.org/text.asp?2013/31/2/204/115240


Dear Editor,

In India, the burden of infectious diseases is enormous and menacing. Diarrhoea is one of the common causes for infant mortality. Laribacter hongkongensis is one of the emerging bacterial pathogens causing gastroenteritis and traveller's diarrhoea, first isolated in Hong Kong in 2001. L. hongkongensis is a gram-negative sea-gull shaped bacillus, non-fermentative facultative anaerobe; catalase, oxidase, urease, arginine dihydrolase positive; nitrate reducing and cultivable onto MacConkey agar with cefoperazone (32 μg/ml). Taxonomically this bacterium belongs to family  Neisseria More Detailsceae of β subclass of Proteobacteria.[1] Carp varieties of fishes and edible frogs of fresh water ecosystem are a natural source of infection to human.

Deoxyribonucleic acid analysis revealed that it can survive in the gut environment through acid and urease resistance, adhesion to the intestine and possession of bile salts efflux pump. Catalase and putative superoxide dismutase helps in evading the host defence. Expression of N-acetyl-L-glutamate kinase in the arginine biosynthesis pathway at the different host temperature might support for its adaptation. The tendency for invasion, auto-aggregation, bio-film formation and cytotoxicity with virulence factors such as collagenases, cytotoxins, haemolysins, repeats in toxin, lipopolysaccharides, patatin-like proteins and phospholipase A1 enhances its pathogenicity. [2] It also possess genes for class I integron, different family of proteins and multi-drug resistance. [3]

Though its initial discovery is in Hong Kong, later reports showed its isolation from Hangzhou city, People's Republic of China, Switzerland, Africa and Central America. As of now there is no report on isolation or identification of L. hongkongensis in Indian subcontinent. This information therefore might provide a brief insight about the pathogen and helps in inspection for its presence in near future.


 ~ Acknowledgement Top


Authors would like to thank the management of VIT University, Vellore, India, for cultivation of science and technology.

 
 ~ References Top

1.Yuen KY, Woo PC, Teng JL, Leung KW, Wong MK, Lau SK. Laribacter hongkongensis gen. nov., sp. nov., a novel gram-negative bacterium isolated from a cirrhotic patient with bacteremia and empyema. J Clin Microbiol 2001; 39:4227-32.  Back to cited text no. 1
    
2.Woo PC, Lau SK, Tse H, Teng JL, Curreem SO, Tsang AK, et al. The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats. PLoS Genet 2009; 5:e1000416.  Back to cited text no. 2
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3.Lau SK, Wong GK, Tsang AK, Teng JL, Fan RY, Tse H, et al. Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: A genome-wide analysis. Cell Biosci 2011;1:17.  Back to cited text no. 3
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