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Year : 2012  |  Volume : 30  |  Issue : 3  |  Page : 350-351

Doripenem vs meropenem against Pseudomonas and Acinetobacter


Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, 160 017, India

Correspondence Address:
V Gautam
Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, 160 017
India
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Source of Support: This work was supported by Ranbaxy Intensiva, India and Astra Zeneca Pvt. Ltd., India, Conflict of Interest: None


DOI: 10.4103/0255-0857.99502

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Recently, doripenem has been approved for the treatment of nosocomial pneumonia (NP), including ventilator-associated pneumonia (VAP). The E-test was performed to determine the MICs of doripenem and meropenem in 203 endotracheal aspirate isolates that consisted of 140 Acinetobacter calcoaceticus-Acinetobacter baumannii complexes and 63 Pseudomonas aeruginosa. Doripenem showed minimum concentration necessary for inhibition of 50% (MIC 50 ) of P. aeruginosa isolates at 0.38 mg/L which is several times (84.2 times) lower than the corresponding MIC 50 value of >32 mg/L for meropenem. The MIC 50 and MIC 90 were similar for both the drugs against A. baumannii. Thus, P. aeruginosa was consistently more susceptible than the A. baumannii.






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