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Year : 2012  |  Volume : 30  |  Issue : 2  |  Page : 227-229

Relapse of kala-azar after use of multiple drugs: A case report and brief review of literature

1 Everest International Clinic and Research Center, Kathmandu, Nepal
2 Everest International Clinic and Research Center; Clinical Research Unit, Department of Medicine Sukraraj Tropical and Infectious Disease Hospital, Kathmandu, Nepal

Correspondence Address:
K Pandey
Everest International Clinic and Research Center, Kathmandu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0255-0857.96703

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We present a case of kala-azar infection that recurred in a patient after completion of the standard treatment course of miltefosine, amphotericin B-deoxycholate (short course), and amphotericin B lipid formulations. The patient was cured after continuous amphotericin B-deoxycholate administration for 4 weeks. This is a unique case of relapse following the use of three important drugs. Although amphotericin B-deoxycholate is a second line drug in Nepal, it has shown a satisfactory clinical response with continuous treatment for 4 weeks. Therefore, an extended course of amphotericin B-deoxycholate may be beneficial in patients with resistance to the standard short course and other anti-leishmania drugs.


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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

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