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Year : 2011  |  Volume : 29  |  Issue : 4  |  Page : 414-417

Complement-dependent lymphocytotoxicity crossmatch in deceased donor renal transplant: A single institutional experience


Institute of Microbiology, Madras Medical College and Rajiv Gandhi Govt. General Hospital, Chennai 600 003, India

Correspondence Address:
R Deepa
Institute of Microbiology, Madras Medical College and Rajiv Gandhi Govt. General Hospital, Chennai 600 003
India
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DOI: 10.4103/0255-0857.90182

PMID: 22120805

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Complement-dependent lymphocytotoxicity crossmatches (n=217) between 47 deceased donors and 150 potential renal recipients were retrospectively studied. A negative cross match was reported in 48 (22.1%), doubtful positive in 126 (58.1%), weakly positive in 32 (14.7%) and positive in 11 (5.1%). No autoantibodies were detected. Renal transplantation was performed in 35.5% of the potential recipients. There was no incidence of hyperacute rejection. The graft survival rate was 88% at 15 months of follow up. The study concludes that a negative pretransplant lympocytotoxicity crossmatch using the basic National Institute of Health technique eliminates hyperacute rejection, but carries drawbacks, which require modification and supplementation with more sensitive and specific assays.






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