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Year : 2009  |  Volume : 27  |  Issue : 1  |  Page : 40-43

Investigation of T cell receptors in the peripheral blood of patients with active pulmonary tuberculosis


1 Department of Immunology, Faculty of Medicine, Firat University, Elazig 23119, Turkey
2 Department of Chest Diseases, Faculty of Medicine, Firat University, Elazig 23119, Turkey
3 Department of Clinical Microbiology and Infectious Diseases, Faculty of Medicine, Firat University, Elazig 23119, Turkey

Correspondence Address:
H H Akbulut
Department of Immunology, Faculty of Medicine, Firat University, Elazig 23119
Turkey
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Source of Support: None, Conflict of Interest: None


PMID: 19172058

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T cells have the capability of recognizing target cells through their T cell receptors (TCRs). Thus, the percentages of CD3 +/ gamma-delta (γδ) TCR+ and CD3 +/ alpha-beta (αβ) TCR+ T lymphocytes were investigated in active and inactive pulmonary tuberculosis (PT) patients and in healthy individuals. CD3 + and CD3 +/αβ TCR+ cell percentages were significantly lower in all PT patients than in healthy subjects. Percentages of CD3 +/γδ and CD3+/αβ TCR+ were not statistically different between active and inactive PT patients. It was concluded that αβ TCR+ T cells might have a protective role in tuberculosis infection.






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2004 - Indian Journal of Medical Microbiology
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