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Year : 2008  |  Volume : 26  |  Issue : 4  |  Page : 349-351

Study of metallo-β-lactamase production in clinical isolates of Pseudomonas aeruginosa


Department of Microbiology, Indira Gandhi Government Medical College, Nagpur - 444 018, India

Correspondence Address:
S V Jalgaonkar
Department of Microbiology, Indira Gandhi Government Medical College, Nagpur - 444 018
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0255-0857.43573

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A study of metallo-β-lactamase (MBL) production was done in clinical isolates of Pseudomonas aeruginosa . Isolates resistant to ceftazidime and imipenem were screened for MBL production by double disc synergy test (DDST) and minimum inhibitory concentration reduction test. There was complete correlation between two methods for imipenem. For ceftazidime, there was correlation between the two methods in all except four strains. In the screening test for MBL, ceftazidime - EDTA combination was better than imipenem - EDTA combination. 8.05% strains were MBL producers. Presence of MBL producer P. aeruginosa is a cause of concern. Simple DDST can be helpful for monitoring of these emerging resistant determinants.






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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

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