Indian Journal of Medical Microbiology IAMM  | About us |  Subscription |  e-Alerts  | Feedback |  Login   
  Print this page Email this page   Small font sizeDefault font sizeIncrease font size
 Home | Ahead of Print | Current Issue | Archives | Search | Instructions  
Users Online: 4660 Official Publication of Indian Association of Medical Microbiologists 
  Search
 
 ~ Next article
 ~ Previous article 
 ~ Table of Contents
  
 ~  Similar in PUBMED
 ~  Search Pubmed for
 ~  Search in Google Scholar for
 ~Related articles
 ~  Article in PDF (147 KB)
 ~  Citation Manager
 ~  Access Statistics
 ~  Reader Comments
 ~  Email Alert *
 ~  Add to My List *
* Registration required (free)  

 
 ~  Abstract
 ~  Case Report
 ~  Discussion
 ~  References
 ~  Article Figures

 Article Access Statistics
    Viewed4163    
    Printed116    
    Emailed0    
    PDF Downloaded266    
    Comments [Add]    
    Cited by others 12    

Recommend this journal

 


 
CASE REPORT
Year : 2008  |  Volume : 26  |  Issue : 3  |  Page : 269-271
 

Apophysomyces elegans - renal mucormycosis in a healthy host: A case report from south India


1 Department of Urology, Christian Medical College, Vellore - 632 004, Tamil Nadu, India
2 Department of Pathology, Christian Medical College, Vellore - 632 004, Tamil Nadu, India
3 Department of Microbiology, Christian Medical College, Vellore - 632 004, Tamil Nadu, India

Date of Submission25-Jan-2008
Date of Acceptance04-Feb-2008

Correspondence Address:
A J Thomas
Department of Urology, Christian Medical College, Vellore - 632 004, Tamil Nadu
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0255-0857.42048

Rights and Permissions

 ~ Abstract 

Zygomycosis is an opportunistic fungal infection that seldom occurs in individuals with a competent immune system. Isolated involvement of any organ is rare and only a few cases of renal zygomycosis have been reported. We present an unusual case of renal zygomycosis caused by Apophysomyces elegans in a patient with no known predisposing factor. He presented with flakes in the urine and was found to have a poorly functioning right kidney. Ureterorenoscopy was performed, fungal elements removed and pathological confirmation obtained. The patient subsequently underwent nephrectomy after treatment with amphotericin B. He made an uneventful recovery.


Keywords: Apomycophyses elegans, renal mucormycosis


How to cite this article:
Thomas A J, Shah S, Mathews M S, Chacko N. Apophysomyces elegans - renal mucormycosis in a healthy host: A case report from south India. Indian J Med Microbiol 2008;26:269-71

How to cite this URL:
Thomas A J, Shah S, Mathews M S, Chacko N. Apophysomyces elegans - renal mucormycosis in a healthy host: A case report from south India. Indian J Med Microbiol [serial online] 2008 [cited 2019 Dec 6];26:269-71. Available from: http://www.ijmm.org/text.asp?2008/26/3/269/42048


Zygomycosis (mucormycosis) is caused by fungi of the order Mucorales and most commonly by organisms belonging to genus Rhizopus . Others include Absidia, Mucor, Apophyomyces and Saksenaea . [1],[2] Renal involvement in disseminated mucormycosis occurs in up to 19% of patients. [3] Isolated renal zygomycosis (mucormycosis) is extremely rare. Only few cases caused by varied species have been reported. [1],[4],[5],[6],[7],[8],[9] To the best of our knowledge, this is the first report of renal zygomycosis (mucormycosis) caused by Apophysomyces elegans from the south of the country, in a patient who was otherwise healthy.


 ~ Case Report Top


A 41-year-old male presented on 2 nd March 2006 to the urology out patient department at the authors' institution with passage of whitish flakes in the urine for three months. He had occasional burning micturition and a vague ache in the right flank, neither of which was bothersome. There was no fever, haematuria, calculuria, and loss of appetite or weight. He was not a diabetic but was recently detected to be hypertensive. He denied any history of surgical intervention or instrumentation.

Physical examination was normal. A preoperative intravenous urogram revealed faint opacification of the right pelvicalyceal system with mild hydronephrosis [Figure 1]. The right ureter was not visualised. The left side was normal. Urinary tests for acid fast bacilli (AFB) were negative. On cystoscopy, the urethra, ureteric orifices and bladder were normal. A retrograde pyelogram revealed a dilated ureter with filling defects in the ureter and pelvicalyceal system. Ureterorenoscopy disclosed fluffy dirty grey material in the ureter and pelvicalyceal system. Some of this was removed through the ureterorenoscope and sent for culture and histopathology examination. Direct microscopy of the material revealed aseptate fungal hyphae morphologically suggestive of zygomycetes. On culture of the material the organism was identified as Apophysomyces elegans [Figure 2]. A preoperative CT revealed residual fungal material in the right pelvicalyceal system [Figure 3]. He was subsequently treated with amphotericin B and underwent right nephrectomy. His recovery was uneventful and is asymptomatic after 6 months of follow up. His urine culture showed no growth


 ~ Discussion Top


Zygomycosis in humans is rare and the condition even rarer when patient is healthy with absent predisposing factors. [3],[10] To our knowledge, this is the first case to be reported from South India where a healthy individual presented with an isolated renal zygomycosis. The largest series of zygomycoses had 129 patients of which 11 had isolated involvement of kidneys. Apophysomyces elegans was isolated in only one patient. It is unclear whether this patient was asymptomatic. [3]

Working differential diagnoses of renal TB and fungal bezoars were considered before proceeding to obtain a definitive diagnosis on histology and microbiological studies. Once the tissue confirmation was received a literature search was made on the mode of management. It is widely agreed that an aggressive approach needs to be pursued in order to care for what is believed to be a condition with a high mortality. [10] Treatment with anti-fungals preferably amphotericin B, followed with early nephrectomy is probably the best approach. [3] The patient received amphotericin B (0.6 mg/kg/day) and a nephrectomy was performed two days later. The antifungal treatment was continued for five days post operatively.

Most reports are cases with a predisposing factor leading to a compromised immune status like diabetes, AIDS, drug abuse, and transplant recipients. [4],[5],[6],[7],[8],[9] It is not known whether they can present with minimal constitutional symptoms in a healthy individual. Also not known is whether a course of amphotericin B after the endoscopic removal of the fungal bezoars would have sufficed in an otherwise healthy patient like this. Since the fungus has a propensity to invade the blood vessels and cause infarction, drug penetration into the affected tissue remains inadequate - hence the need for a nephrectomy. [6] Rogenes et al , did a literature search of all such case reports and concluded that none of the cases that underwent a conservative line of management survived, in spite of receiving amphotericin B. [10] Only one patient who did not receive the drug is known to have survived. [10] Overall survival for isolated renal zygomycosis is estimated to be 65%. [10].

 
 ~ References Top

1.Raghavan R, Date A, Bhaktaviziam A. Fungal and nocardial infections of the kidney. Histopathology 1987;11:9-20.  Back to cited text no. 1  [PUBMED]  
2.Mathews MS, Raman A, Nair A. Nosocomial zygomycotic post-surgical necrotizing fasciitis in a healthy adult caused by Apophysomyces elegans in South India. J Med Vet Mycol 1997;35,61-3.  Back to cited text no. 2    
3.Chakrabarti A, Das A, Sharma A, Panda N, Das S, Gupta KL, et al . Ten years' experience in zygomycosis at a tertiary care centre in India. J Infect 2001;42:261-6.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]
4.Davila RM, Moser SA, Grosso LE. Renal mucormycosis: A case report and review of the literature. J Urol 1991;145:1242-4.  Back to cited text no. 4  [PUBMED]  
5.Pickles R, Long G, Murugasu R. Isolated renal mucormycosis. Med J Aust 1994;160:514-6.  Back to cited text no. 5  [PUBMED]  
6.Langston C, Roberts DA, Porter GA, Bennett WM. Renal phycomycosis. J Urol 1973;109:941-4.  Back to cited text no. 6  [PUBMED]  
7.Low AI, Tulloch AG, England EJ. Phycomycosis of the kidney associated with a transient immune defect and treated with clotrimazole. J Urol 1974;111:732-4.  Back to cited text no. 7  [PUBMED]  
8.Flood HD, O'Brien AM, Kelly DG. Isolated renal mucormycosis. Postgrad Med J 1985;61:175-6.  Back to cited text no. 8  [PUBMED]  
9.Santos J, Espigado P, Romero C, Andreu J, Rivero A, Pineda JA. Isolated renal mucormycosis in two AIDS patients. Eur J Clin Microbiol Infect Dis 1994;13:430-2.  Back to cited text no. 9  [PUBMED]  
10.Rogenes V, Vick S, Pulitzer DR. Isolated renal mucormycosis. Infect Urol 1998;113:78-83.  Back to cited text no. 10    


    Figures

  [Figure 1], [Figure 2], [Figure 3]

This article has been cited by
1 Biology, systematics, and clinical manifestations of Zygomycota infections
A. Muszewska,J. Pawlowska,P. Krzysciak
European Journal of Clinical Microbiology & Infectious Diseases. 2014;
[Pubmed] | [DOI]
2 Isolated Renal Mucormycosis in a Healthy Immunocompetent Patient: Atypical Presentation and Course
Mrinal Pahwa,Archna R. Pahwa,Mohit Girotra,Arun Chawla
Korean Journal of Urology. 2013; 54(9): 641
[Pubmed] | [DOI]
3 Epidemiology of Mucormycosis in India
Arunaloke Chakrabarti,Manpreet Dhaliwal
Current Fungal Infection Reports. 2013;
[Pubmed] | [DOI]
4 Mucormycosis and acute kidney injury
Krishan L Gupta,Aakriti Gupta
Journal of Nephropathology. 2012; 1(3): 155
[Pubmed] | [DOI]
5 Mucormycosis in immunocompetent patients: a case-series of patients with maxillary sinus involvement and a critical review of the literature
Michele D. Mignogna, Giulio Fortuna, Stefania Leuci, Daniela Adamo, Elvira Ruoppo, Maria Siano, Umberto Mariani
International Journal of Infectious Diseases. 2011;
[VIEW] | [DOI]
6 Renal mucormycosis in immunocompetent patients: Report of three cases : Isolated renal mucormycosis
Ritu Verma, Mukul Vij, Vinita Agrawal, Manoj Jain
Basic and Applied Pathology. 2011; 4(2): 66
[VIEW] | [DOI]
7 Emerging role of radiological criteria for antemortem diagnosis of renal zygomycosis: an uncommon cause of acute renal failure
P. Ranjan, R. Naval, R. Singh, R. K. Gupta, R. Kapoor, R. K. Sharma
NDT Plus. 2011;
[VIEW] | [DOI]
8 Successful medical management of renal zygomycosis: a summary of two cases and a review of the Indian literature
Rungmei S. K. Marak,Richa Misra,M. S. Ansari,Ajai Dixit,Ajai Poornima,K. N. Prasad,T. N. Dhole
Medical Mycology. 2010; 48(8): 1088
[Pubmed] | [DOI]
9 Apophysomyces elegans: Epidemiology, amplified fragment length polymorphism typing, and in vitro antifungal susceptibility pattern
Chakrabarti, A., Shivaprakash, M.R., Curfs-Breuker, I., Baghela, A., Klaassen, C.H., Meis, J.F.
Journal of Clinical Microbiology. 2010; 48(12): 4580-4585
[Pubmed]
10 Successful medical management of renal zygomycosis: A summary of two cases and a review of the Indian literature
Marak, R.S.K., Misra, R., Ansari, M.S., Dixit, A., Poornima, Prasad, K.N., Dhole, T.N.
Medical Mycology. 2010; 48(8): 1088-1095
[Pubmed]
11 Changing epidemiology of an emerging infection: Zygomycosis
Meis, J.F., Chakrabarti, A.
Clinical Microbiology and Infection. 2009; 15(Suppl 5): 10-14
[Pubmed]
12 Changing epidemiology of an emerging infection: zygomycosis
J. F. Meis,A. Chakrabarti
Clinical Microbiology and Infection. 2009; 15: 10
[Pubmed] | [DOI]



 

Top
Print this article  Email this article
Previous article Next article

    

2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04