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Year : 2008  |  Volume : 26  |  Issue : 3  |  Page : 217-221

Evidence for lower CD4+ T cell and higher viral load in asymptomatic HIV-1 infected individuals of India: Implications for therapy initiation

1 Department of Clinical Virology, Christian Medical College, Vellore- 632 004, India
2 Department of Biostatistics, Christian Medical College, Vellore- 632 004, India
3 Department of Internal Medicine, Christian Medical College, Vellore- 632 004, India
4 Department of Dermatology, Christian Medical College, Vellore- 632 004, India

Correspondence Address:
R Kannangai
Department of Clinical Virology, Christian Medical College, Vellore- 632 004
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0255-0857.42031

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Purpose: We have earlier documented that the south Indian population had lower CD4 counts. The aim of this study was to investigate a previous suggestion on a new CD4+ T cell cut off and association with HIV-1 RNA levels for decision on anti retroviral therapy in India (south). Methods: We evaluated a new methodology i.e., artus real-time PCR and CD4+ T cell count by Guava EasyCD4 system. From 146 HIV infected individuals seen at a tertiary care centre, blood was collected for CD4+ T cell and HIV-1 RNA estimation. Results: The receiver operating characteristic curve cut off value for the CD4 counts to distinguish between CDC clinical categories A and B was 243 cells/μL, and to distinguish B and C was 153 cells/μL. The RNA level that differentiated CDC A and B was 327473 RNA copies/mL, while for CDC B and C was 688543 copies/mL. There was a significant negative correlation (r = -0.55, P < 0.01) between the RNA estimated and CD4+ T cell counts in HIV infected individuals. Conclusions: A majority with CD4 counts of 201-350 cells/μL in our population had higher viral load than the treatment threshold suggested by the International AIDS society and the above two methodologies are useful in monitoring HIV infections.


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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04