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CORRESPONDENCE
Year : 2008  |  Volume : 26  |  Issue : 2  |  Page : 205-206
 

Seroprevalence of HIV, hepatitis C and hepatitis B in multitransfused thalassemics


Department of Microbiology, LTM Medical College and Hospital, Sion, Mumbai - 400 022, India

Date of Submission25-Jul-2007
Date of Acceptance26-Sep-2007

Correspondence Address:
M Mathur
Department of Microbiology, LTM Medical College and Hospital, Sion, Mumbai - 400 022
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0255-0857.40552

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How to cite this article:
Mathur M, Wanjari K, Turbadkar D. Seroprevalence of HIV, hepatitis C and hepatitis B in multitransfused thalassemics . Indian J Med Microbiol 2008;26:205-6

How to cite this URL:
Mathur M, Wanjari K, Turbadkar D. Seroprevalence of HIV, hepatitis C and hepatitis B in multitransfused thalassemics . Indian J Med Microbiol [serial online] 2008 [cited 2019 Sep 22];26:205-6. Available from: http://www.ijmm.org/text.asp?2008/26/2/205/40552


Dear editor,

In recent years, there has been increased public concern about the safety of blood transfusion with respect to transfusion-transmitted infections. Human immunodeficiency, Hepatitis B and Hepatitis C viruses are transmissible by blood transfusion and are associated with important clinical diseases. Blood units are screened with assays of steadily increasing sensitivity due to availability of antibodies against Hepatitis B surface antigen (HBsAg) since 1971, [1] against HIV since 1989 and against Hepatitis C virus since 2001. [2]

This study includes 126 multitransfused thalassemia cases (82 males and 44 females) attending LTMG Hospital, Mumbai, over a period of 18 months (January 2002 to June 2003). Patients were in the age group of ten months to 22 years with a mean of 6.7 years with no other risk factors. Blood was collected and serum samples were screened for HBsAg by the enzyme linked immunosorbent assay (ELISA) method (Hepanostika kit). A third generation ELISA kit was used to screen for the antibody to HCV. ELISA and Rapid tests were used to detect antibody to HIV as per national AIDS control organisation (NACO) guidelines. In the present study of 126 multitransfused thalassemia cases, seroprevalence of the antiHIV and antiHCV antibodies and of HBsAg was 3.97, 43.65 and 2.38%, respectively. In thalassemia cases receiving more than 50 transfusions, seroprevalence of the antiHIV and antiHCV antibodies and of the HBsAg was 5.43, 57.6 and 2.38%, respectively [Table - 1].

Blood screening using the viral antigen and nucleic acid amplification tests (NAT) can reduce the window period of HIV, Hepatitis B virus and Hepatitis C virus infections substantially. [3] Estimates of the risk of blood-borne infections are essential for monitoring the safety of blood supply and the impact of new screening tests. Blood transfusion, a life saving modality, can be made safer by the introduction of the NAT for screening of blood units for HIV, Hepatitis B and Hepatitis C viruses and it can be made cost-effective by pooling samples. [4]

 
 ~ References Top

1.Narayan S. Microbes and blood transfusion. Indian J Med Microbiol 2001;19:119-26.  Back to cited text no. 1    
2.Sen S, Mishra NM, Giri T. AIDS in multitransfused children with thalassemia. Indian Pediatr 1993;30:455-60.  Back to cited text no. 2    
3.Kuhns MC, Busch MP. New strategies for blood donor screening for hepatitis B virus: Nucleic acid testing versus immunoassay methods. Mole Diagnost Ther 2006;10:77-91.  Back to cited text no. 3    
4.MHS Newsletter. Manipal: Manipal Health Services; January 5, 2006.  Back to cited text no. 4    



 
 
    Tables

  [Table - 1]

This article has been cited by
1 Transfusion transmitted infections in thalassaemics: need for reappraisal of blood screening strategy in India
V. Shyamala
Transfusion Medicine. 2014; 24(2): 79
[Pubmed] | [DOI]
2 Transfusion Transmitted Infections in Indian Thalassemics: A Perspective
Ajit C. Gorakshakar,Kanjaksha Ghosh
Indian Journal of Hematology and Blood Transfusion. 2013; 29(3): 189
[Pubmed] | [DOI]



 

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