|Year : 2008 | Volume
| Issue : 1 | Page : 94-95
Seroprevalence of rubella among urban and rural Bangladeshi women emphasises the need for rubella vaccination of pre-pubertal girls
A Nessa1, MN Islam1, S Tabassum1, SU Munshi1, M Ahmed1, R Karim2
1 Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahabag, Dhaka, Bangladesh
2 Department of Gynecology and Obstetrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahabag, Dhaka, Bangladesh
|Date of Submission||25-Jun-2007|
|Date of Acceptance||06-Jul-2007|
S U Munshi
Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahabag, Dhaka
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Nessa A, Islam M N, Tabassum S, Munshi S U, Ahmed M, Karim R. Seroprevalence of rubella among urban and rural Bangladeshi women emphasises the need for rubella vaccination of pre-pubertal girls. Indian J Med Microbiol 2008;26:94-5
|How to cite this URL:|
Nessa A, Islam M N, Tabassum S, Munshi S U, Ahmed M, Karim R. Seroprevalence of rubella among urban and rural Bangladeshi women emphasises the need for rubella vaccination of pre-pubertal girls. Indian J Med Microbiol [serial online] 2008 [cited 2020 May 26];26:94-5. Available from: http://www.ijmm.org/text.asp?2008/26/1/94/38877
Rubella virus infection poses a serious threat to the developing foetus if contracted during early pregnancy. In post-rubella vaccination era, endemic rubella and congenital rubella syndrome (CRS) continue to occur in much of the developing world, and Bangladesh is not an exemption.  The present study was designed to report the prevalence of rubella antibody in the female population of different age groups in both rural and urban areas and to find out the susceptible age group and the eligible group for rubella immunization. The study was carried out by the Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from April 2004 to June 2005 with subjects in the age group of 1-45 years. The estimation for rubella-specific IgG was done in the study population consisting of a total of 582 children and women in the child-bearing age.
The average prevalence of rubella antibody was 71.99%, and the prevalence of rubella IgG increased gradually with age. In the 1-5-year age group, the prevalence was found to be 21.31%, which gradually increased with age to reach 90.32% in the 41-45-year age group, excepting a slight drop (2.63%) in 31-35-year age group. A similar trend was observed in both urban and rural females when arranged according to age groups [Table - 1]. The percentage of new cases, i.e., incidence rate, in a specific group was calculated by deducting the total percentage of rubella IgG positives in that group from the percentage of the preceding age group; there was a significant increase (31.14%) in the incidence of infection in the 6-10-year age group ( P < 0.001).
The gradual increase in the prevalence of rubella infection with age indicates a continuous exposure of the population to rubella virus. Similar findings were reported in previous studies from India  as well as in most of the industrialized countries before the introduction of rubella vaccination programme. , The highest incidence of infection occurred in 6-10-year age group, and children become protected from further rubella infection. Although it was thought that population density, area of residence and socioeconomic factors of a given community influence rubella infection, the prevalence of rubella antibody was more or less similar in urban and rural areas. It indicates that the women of both areas are at similar risk of infection to rubella virus in Bangladesh.
In this study, it was seen that 65.20% female children acquired immunity to rubella by the age of 12 years. Thereafter, 25.12% of women in the child-bearing age (i.e., 13-45 years) acquired new infection; if they contracted rubella infection during their early pregnancy, there is a high probability of developing CRS.
World over, 124 countries reported a national policy of rubella vaccination in 2002. Although studies indicate that rubella immunization is a cost-effective means of reducing the impacts of CRS, Bangladesh and other South Asian countries, except Sri Lanka and Maldives, have not yet included this vaccine in their national vaccination system.  In the present study, we found that more than 50% of pre-pubertal girls were immunized by natural infection. As reduction of infant mortality was one of the priority objectives of the Millennium Development Goal, introduction of rubella vaccine in the pre-pubertal age may be beneficial in further reducing infant mortality rate and CRS.
| ~ References|| |
|1.||Nahar N, Islam MN. Prevalence of rubella HI antibody in children and women in Dhaka. Bang Med J 1987;6:1-5. |
|2.||Mathur A, Chaturvedi UC, Mehrotra RM. Serological study for the prevalence of rubella at Lucknow. Indian J Med Res 1974;62:307-12. [PUBMED] |
|3.||Rawls WE, Melnick JL, Bailey M, Ferris AA. WHO collaborative study on the seroepidemiology of rubella. Bull WHO 1967;37:79-88. |
|4.||Cutts FT, Vynnycky E. Modelling the incidence of congenital rubella syndrome in developing countries. Int J Epidemiol 1999;28:1176-84. [PUBMED] [FULLTEXT]|
|5.||Robertson SE, Featherstone DA, Gacic-Dobo M, Hersh BS. Rubella and Congenital Rubella syndrome: global update. Pan Am J Public Health 2003;14:306-15. |
[Table - 1]
|This article has been cited by|
| ||Nessa, A. and Islam, MN and Tabassum, S. and Munshi, SU and Ahmed, M. and Karim, R. and others |
| ||Indian Journal of Medical Microbiology. 2008; 26(1): 94 |