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CORRESPONDENCE
Year : 2008  |  Volume : 26  |  Issue : 1  |  Page : 90
 

Parental history of ulcer and the prevalence of Helicobacter pylori infection in their offspring


1 Centre for Liver Research and Diagnostics, Kanchanbagh, Hyderabad - 500076, Dr Hari Singh Gour University, Sagar, Madhya Pradesh - 470 003, India
2 Centre for Liver Research and Diagnostics, Kanchanbagh, Hyderabad - 500076, India
3 Dr Hari Singh Gour University, Sagar, Madhya Pradesh - 470 003, India

Date of Submission24-Jan-2007
Date of Acceptance01-May-2007

Correspondence Address:
K S Ahmed
Centre for Liver Research and Diagnostics, Kanchanbagh, Hyderabad - 500076, Dr Hari Singh Gour University, Sagar, Madhya Pradesh - 470 003
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0255-0857.38873

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How to cite this article:
Ahmed K S, Khan A A, Ahi J D, Habibullah C M. Parental history of ulcer and the prevalence of Helicobacter pylori infection in their offspring. Indian J Med Microbiol 2008;26:90

How to cite this URL:
Ahmed K S, Khan A A, Ahi J D, Habibullah C M. Parental history of ulcer and the prevalence of Helicobacter pylori infection in their offspring. Indian J Med Microbiol [serial online] 2008 [cited 2019 Jun 18];26:90. Available from: http://www.ijmm.org/text.asp?2008/26/1/90/38873


Dear editor,

Helicobacter pylori infection is present in almost all patients with duodenal ulcers and gastric ulcers. [1] The pathogenic role of H. pylori in peptic ulcer disease is well known. Up to 95% of patients with duodenal ulcers, and 80% of patients with gastric ulcers suffer from this infection. [2] The present study was carried out in the population of south India, which is considered the population at high risk of stomach cancer. [3] We assessed the relationship between subjects with a history of gastric or duodenal ulcer and the risk of infection in their offsprings with the help of PCR assay targeting the 16S rRNA gene. The 16S rRNA gene is a highly specific target for amplification and has been previously of help in reclassifying the organism. [4] Another scientist demonstrated the specificity of unique H. pylori gene primer in identifying the organism in paraffin-embedded gastric biopsy specimen.

The subjects referred to for upper gastrointestinal endoscopy at Deccan College of Medical Sciences and Research Center, Hyderabad, were interviewed about their mother or father had been referred for endoscopy with the same symptoms or any history of ulcer. The questionnaire sought details on risk factors for H. pylori infection, such as housing conditions, family demographics and socioeconomic factors. By 16S rRNA amplification, the status of H. pylori was confirmed. A total of 160 subjects were enrolled in the study, of which 70 subjects reported a parental history (mother or father) of ulcer, and 90 were without any history of ulcer. Of a total of 70 subjects, 14.2% were H. pylori negative and 85.7% were H. pylori positive (10 and 60, respectively). In those with no family history of ulcer, the prevalence of H. pylori was 80% and 20% H. pylori negative (72 and 18, respectively, of 90). The results propose the hypotheses that the transmission of H. pylori may be influenced by the presence of ulcer or that H. pylori strains causing peptic ulcer may be more infective than other strains as published in earlier studies. [5] This may be because of the relation between a history of ulcer and H. pylori infection in his or her family or due to common environmental or genetic factors that influence susceptibility to infection. In addition, the high prevalence of H. pylori infection in subjects with no family history of ulcer suggests how the living conditions, socioeconomic factors and cultural background of the subjects are important in mounting the prevalence and transmission of H. pylori infection.

 
 ~ References Top

1.NIH Consensus Conference. Helicobacter pylori in peptic ulcer disease. JAMA 1994;272:659.  Back to cited text no. 1    
2.Breuer T, Goodman KJ, Malaty HM, Sudhop T, Graham DY. How do clinicians practicing in the U.S. manage Helicobacter pylori -related gastrointestinal diseases? A comparison of primary care and specialist physicians. Am J Gastroenterol 1998;93:553-61.  Back to cited text no. 2    
3.Gajalakshmi CK, Shanta V. Lifestyle and risk of stomach cancer: A hospital-based case-control study. Int J Epidemiol 1996;25:1146-53.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]
4.Ahmed KS, Khan AA, Ahmed I, Tiwari SK. Prevalence study to elucidate the transmission pathways of Helicobacter pylori at oral and gastroduodenal sites of a South Indian population. Singapore Med J 2006;47:291-6.  Back to cited text no. 4    
5.Brenner H, Rothenbacher D, Bode G, Adler G. Parental history of gastric or duodenal ulcer and prevalence of Helicobacter pylori infection in preschool children: population based study. BMJ 1998;316:665.  Back to cited text no. 5  [PUBMED]  [FULLTEXT]




 

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