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 ORIGINAL ARTICLE
Year : 2008  |  Volume : 26  |  Issue : 1  |  Page : 25-28

Effect of exposure to hydrogen peroxide on the virulence of Escherichia coli


Department of Microbiology, Kasturba Medical College, Mangalore - 575 001, Karnataka, India

Correspondence Address:
G K Bhat
Department of Microbiology, Kasturba Medical College, Mangalore - 575 001, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0255-0857.38853

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Purpose: To eliminate pathogenic bacteria, the host presents conditions that are stressful for bacteria. Oxidative stress arises when the concentration of pro-oxidants like hydrogen peroxide (H 2 O 2 ) and superoxide anion increases to a level over the basal defence capacity of the cell. In the present study, we studied the effect of oxidative stress on the production of certain virulence factors by Escherichia coli . Methods: E. coli was exposed to oxidative stress by growing in the presence of different concentrations of H 2 O 2 . The effect of oxidative stress on the expression of surface hydrophobicity, adherence, haemolysin production, serum resistance and phagocytosis was studied. Results: Oxidative stress caused a significant decrease in the expression of all the virulence factors of E. coli . Conclusions: Synthesis of virulence factors can be significantly altered by oxidative stress and such changes may affect the pathogenicity of E. coli.






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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

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