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Year : 2007  |  Volume : 25  |  Issue : 3  |  Page : 260-262

Aciclovir resistance among indian strains of Herpes simplex virus as determined using a dye uptake assay


1 Department of Clinical Virology, Christian Medical College, Vellore - 632 004, Tamil Nadu, India
2 Department of Dermatology, Christian Medical College, Vellore - 632 004, Tamil Nadu, India
3 Royal Free and University College Medical School, Windeyer Institute, London, W1T 4JF, United Kingdom
4 L and T Microbiology Research Centre, Sankara Nethralaya, Chennai - 600 006, Tamil Nadu, India
5 Department of Clinical Microbiology, Christian Medical College, Vellore - 632 004, Tamil Nadu, India

Correspondence Address:
A M Abraham
Department of Clinical Virology, Christian Medical College, Vellore - 632 004, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0255-0857.34771

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Resistance to aciclovir (ACV) among Herpes simplex virus (HSV) isolates is increasingly being reported in the literature particularly in immunocompromised patients. However, there is only limited data available from India despite widespread use of ACV in our hospital. A cross-sectional study was hence conducted to determine the aciclovir (ACV) susceptibility of HSV 1 and 2 isolates using a dye uptake (DU) assay. This study showed a 3.0% prevalence of ACV resistance among HSV-1 strains (2/66, median IC 50 0.098 g/mL) while in HSV-2 strains, it was 7.8% (5/64, median IC 50 0.195 g/mL). The IC 50 for the HSV-1 and HSV-2 strains resistant to ACV was greater than or equal to 6.25 g/mL.






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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

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