Indian Journal of Medical Microbiology IAMM  | About us |  Subscription |  e-Alerts  | Feedback |  Login   
  Print this page Email this page   Small font sizeDefault font sizeIncrease font size
 Home | Ahead of Print | Current Issue | Archives | Search | Instructions  
Users Online: 43 Official Publication of Indian Association of Medical Microbiologists 
  Search
 
 ~ Next article
 ~ Previous article 
 ~ Table of Contents
  
 ~  Similar in PUBMED
 ~  Search Pubmed for
 ~  Search in Google Scholar for
 ~  Article in PDF (84 KB)
 ~  Citation Manager
 ~  Access Statistics
 ~  Reader Comments
 ~  Email Alert *
 ~  Add to My List *
* Registration required (free)  

 
 ~  References
 ~  Article Tables

 Article Access Statistics
    Viewed3141    
    Printed64    
    Emailed0    
    PDF Downloaded225    
    Comments [Add]    
    Cited by others 6    

Recommend this journal

 


 
CORRESPONDENCE
Year : 2007  |  Volume : 25  |  Issue : 2  |  Page : 174-175
 

Study of Human Immunodeficiency Virus and HCV infections in intravenous drug users in Mumbai


Department of Microbiology, T N Medical College and BYL Nair Children Hospital, Mumbai - 400 008, Maharashtra, India

Correspondence Address:
A Dutta
Department of Microbiology, T N Medical College and BYL Nair Children Hospital, Mumbai - 400 008, Maharashtra
India
Login to access the Email id


DOI: 10.4103/0255-0857.32735

PMID: 17582199

Get Permissions



How to cite this article:
Saraswathi K, Dutta A. Study of Human Immunodeficiency Virus and HCV infections in intravenous drug users in Mumbai. Indian J Med Microbiol 2007;25:174-5

How to cite this URL:
Saraswathi K, Dutta A. Study of Human Immunodeficiency Virus and HCV infections in intravenous drug users in Mumbai. Indian J Med Microbiol [serial online] 2007 [cited 2014 Oct 23];25:174-5. Available from: http://www.ijmm.org/text.asp?2007/25/2/174/32735


Dear Editor,

Drug abuse and human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) are global public health problems. Intravenous drug use accounts for about one-third of all AIDS cases and one-half of hepatitis C cases. [1] It is the major mode of transmission of HIV, apart from high-risk sexual behavior, sharing of needles and other equipment. [2] Past few years have seen emerging recognition of hepatitis C viral infection amongst intravenous drug users (IDUs). Co-infected patients are more likely to progress to chronic liver disease and cirrhosis over a shorter period of time.

This study was carried out from July 2004 to September 2004 at the Department of Microbiology, T. N. Medical College (TNMC) and BYL Nair Children Hospital, Mumbai. The target group comprised of persons who had been taking drugs intravenously for the last three months and they were identified by a drug de-addiction center. Two hundred fifty blood samples were collected by outreach strategy and subjected to HIV-antibody testing and HCV-antibody testing. Testing was unlinked and anonymous, as per Strategy II, CDC guidelines.

Out of 250 IDUs, 74 (30%) tested positive for antibodies to HIV 1 and 153 (61.2%) were positive for antibodies to HCV [Table - 1]. Out of 74 HIV-positive IDUs, 68 (91.06%) were co-infected with HCV. Only HIV 1 was detected. The target population was urban in locale. The lowest age of entry to intravenous drug use was 13 years, oldest being 49 years. One hundred twenty-seven (51%) of the IDUs were in the age group of 20-29 years and 243 (97.2%) were males. All the 74 HIV-positive IDUs and 68 co-infected IDUs were males. Migrants (70.8%) were in majority, while 52% were illiterate and 82.4% were unskilled workers.

In our the study, prevalence of HIV infection amongst intravenous drug users was 30%, which is similar to previous reports. [1],[2] Only HIV 1 infection was detected, although there have been reports of HIV 2 infection among IDUs. [2] Prevalence of HCV infection was 61.2%, which is lower in comparison to a previous study. [3] There was a higher prevalence of HCV infection (61.2%) as compared to HIV infection (30%), which is consistent with a previous study. [3]

A large number (92%) of HIV-positive IDUs were also HCV-positive. Studies outside India also report such findings. [4] Most studies suggest that HIV-positive persons with HCV infection are more likely to progress to chronic liver disease and cirrhosis than HIV-negative persons with HCV infections and may do so more rapidly. Our findings have treatment implications, as antiretroviral therapy may be problematic because of hepatotoxicity.



 
 ~ References Top

1.Pal BB, Khuntai HK, Acharya AS, Chhotray GP. Drug abusers - A new high-risk population for HIV infection in Orissa. Indian J Med Microbiol 2003; 21: 262-4.   Back to cited text no. 1    
2.Singh Ng B, Panda S, Naik TN, Agarwal A, Singh HL, Deb BC. HIV2 strikes injecting drug users (IDUs) in India. J Infect 1995; 31 :49-50.  Back to cited text no. 2    
3.Devi KS, Singh NB, Mara J, Singh TB,Singh YM. Seroprevalence of Hepatitis B Virus and Hepatitis C Virus among Hepatic disorders and Injecting Drug users in Manipur - A preliminary Report. J Med Microbiol 2004; 22 :136-7.  Back to cited text no. 3    
4.Mohsen AH, Murad S, Easter Brook PJ. Prevalence of Hepatitis C in an ethnically diverse HIV-1 infected cohort in South London. HIV Med 2005; 6: 206-15.  Back to cited text no. 4    



 
 
    Tables

  [Table - 1]

This article has been cited by
1 Seroprevalence of anti-hepatitis C virus (anti-HCV) antibody and HCV-related risk in injecting drug users in northern India: Comparison with non-injecting drug users
Debasish Basu,Vineet Kumar,Arun Kumar Sharma,Pawan Kumar Barnwal,Surendra Kumar Mattoo
Asian Journal of Psychiatry. 2013; 6(1): 52
[Pubmed]
2 The intersection between sex and drugs: A cross-sectional study among the spouses of injection drug users in Chennai, India
Solomon, S.S., Srikrishnan, A.K., Celentano, D.D., Johnson, S.C., Vasudevan, C.K., Murugavel, K.G., Anand, S., (...), Mehta, S.H.
BMC Public Health. 2011; 11(art 39)
[Pubmed]
3 The profile of injection drug users in Chennai, India: Identification of risk behaviours and implications for interventions
Solomon, S.S., Desai, M., Srikrishnan, A.K., Thamburaj, E., Vasudevan, C.K., Kumar, M.S., Solomon, S., Mehta, S.H.
Substance Use and Misuse. 2010; 45(3): 354-367
[Pubmed]
4 Overview of Substance Abuse and Hepatitis C Virus Infection and Co-infections in India
Debasish Basu
Journal of Neuroimmune Pharmacology. 2010; 5(4): 496
[VIEW]
5 The Profile of Injection Drug Users in Chennai, India: Identification of Risk Behaviours and Implications for Interventions
Sunil S. Solomon,Monica Desai,A.K. Srikrishnan,Easter Thamburaj,C.K. Vasudevan,M. Suresh Kumar,Suniti Solomon,David D. Celentano,Shruti H. Mehta
Substance Use & Misuse. 2010; 45(3): 354
[Pubmed]
6 Editorial: Emerging trends in viral sexually transmitted infections in India
Dhawan, J., Khandpur, S.
Indian Journal of Dermatology, Venereology and Leprology. 2009; 75(6): 561-565
[Pubmed]



 

Top
Print this article  Email this article
Previous article Next article

    

2004 - Indian Journal of Medical Microbiology
Published by Medknow

Online since April 2001, new site since 1st August '04