Indian Journal of Medical Microbiology IAMM  | About us |  Subscription |  e-Alerts  | Feedback |  Login   
  Print this page Email this page   Small font sizeDefault font sizeIncrease font size
 Home | Ahead of Print | Current Issue | Archives | Search | Instructions  
Users Online: 557 Official Publication of Indian Association of Medical Microbiologists 
  Search
 
 ~ Next article
 ~ Previous article 
 ~ Table of Contents
  
 ~  Similar in PUBMED
 ~  Search Pubmed for
 ~  Search in Google Scholar for
 ~  Article in PDF (39 KB)
 ~  Citation Manager
 ~  Access Statistics
 ~  Reader Comments
 ~  Email Alert *
 ~  Add to My List *
* Registration required (free)  

 
 ~  References
 ~  Article Tables

 Article Access Statistics
    Viewed2853    
    Printed57    
    Emailed0    
    PDF Downloaded145    
    Comments [Add]    

Recommend this journal

 


 
CORRESPONDENCE
Year : 2006  |  Volume : 24  |  Issue : 4  |  Page : 306-307
 

Five-year follow-up of hepatitis B surface antigen positive healthy voluntary blood donors: A preliminary observation


Department of Internal Medicine, James J. Peters VA Medical Center, Mount Sinai School of Medicine, 130 W Kingsbridge Road, NY 10468, USA

Date of Submission13-Dec-2005
Date of Acceptance02-Jan-2006

Correspondence Address:
A K Singal
Department of Internal Medicine, James J. Peters VA Medical Center, Mount Sinai School of Medicine, 130 W Kingsbridge Road, NY 10468
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0255-0857.29403

Rights and Permissions



How to cite this article:
Singal A K. Five-year follow-up of hepatitis B surface antigen positive healthy voluntary blood donors: A preliminary observation. Indian J Med Microbiol 2006;24:306-7

How to cite this URL:
Singal A K. Five-year follow-up of hepatitis B surface antigen positive healthy voluntary blood donors: A preliminary observation. Indian J Med Microbiol [serial online] 2006 [cited 2019 Sep 19];24:306-7. Available from: http://www.ijmm.org/text.asp?2006/24/4/306/29403


Dear Editor,

Data on the profile and outcome of healthy voluntary blood donors (VBDs) who are detected incidentally to be hepatitis B surface antigen (HBsAg) positive at the time of blood donation are scanty. We studied 45 such subjects (M: F 40:5; average age of 27 years) at the Tirath Ram Shah Hospital, Delhi. At presentation they were assessed with clinical examination, liver function tests, serological tests (HBeAg, anti-HBe and HBVDNA), alfa-feto protein (AFP) and ultrasound (USG). All the subjects were followed-up for five years (July 2000 to June 2005) with clinical and biochemical assessment every six months and serological assessment with AFP and USG every year.

Five of these 45 (11%) were positive for HBeAg [Table]. Two subjects (Group II) had pre-core mutant infection.[1] On follow up, none of the subjects from any group had clinical / biochemical deterioration or had developed HCC. Two subjects from Group III cleared HBsAg, whereas, in the rest 43 subjects serological profile remained the same on follow up. The benign course as reported in this observation is in agreement with other studies.[2],[3] However, there are contrary reports in the literature.[4] This is likely to be due to theheterogeneous study group in the report by Chandra et al .[4] It is known that hepatitis B can lead to serious consequences such as cirrhosis and HCC. Moreover, there are reports of these sequel even after development of anti-HBs antibodies.[5] It is therefore, mandatory for HBsAg positive subjects to have a regular follow-up. Although the short-term outcome of five years on HBsAg positive healthy VBDs is observed to be quite good, there is a clear need to derive long- term follow-up data on these subjects.

 
 ~ References Top

1.Locarnini S, Bartholomeusz A, Hepatitis B virus mutants: Clinical presentation, diagnosis and management. In : Hepatitis B in India: Prevention and Management . Sarin SK, Singal AK, editors. CBS Publishers and Distributors: New Delhi; 2004. p. 127-47.  Back to cited text no. 1    
2.deFranchis R, Meucci G, Vecchi M, Tatarella M, Colombo M, Del Ninno E, et al . The natural history of asymptomatic HBsAg carriers. Ann Intern Med 1993; 118 :191-4.  Back to cited text no. 2    
3.Villeneuve JP, Desrochers M, Infante-Rivard C, Willems B, Raymond G, Bourcier M, et al . A long term follow up study of asymptomatic hepatitis B surface antigen positive carriers in Montreal. Gastroenterology 1994; 196 :1000-5.  Back to cited text no. 3    
4.Chandra R, Kapoor D, Agarwal SR, Malhotra V, Sakhuja P, Sarin SK. Profile of chronic asymptomatic HBV infection in India. Indian J Med Res 2002; 116 :50-7.  Back to cited text no. 4  [PUBMED]  
5.Huo TI, Wu JC, Lee PC, Chau GY, Lui WY, Tsay SH, et al . Sero-clearnace of HBsAg in chronic carriers does not necessarily imply a good prognosis. Hepatology 1998; 28 :231-6.  Back to cited text no. 5    


    Tables

[Table - 1]



 

Top
Print this article  Email this article
Previous article Next article

    

2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04