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Year : 2006  |  Volume : 24  |  Issue : 1  |  Page : 76-77
 

Neonatal septicaemia by Salmonella paratyphi B


Department of Microbiology, Subharati Medical College, Meerut - 250 002, Uttar Pradesh, India

Correspondence Address:
R Malenie
Department of Microbiology, Subharati Medical College, Meerut - 250 002, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0255-0857.19906

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How to cite this article:
Malenie R. Neonatal septicaemia by Salmonella paratyphi B. Indian J Med Microbiol 2006;24:76-7

How to cite this URL:
Malenie R. Neonatal septicaemia by Salmonella paratyphi B. Indian J Med Microbiol [serial online] 2006 [cited 2019 Nov 19];24:76-7. Available from: http://www.ijmm.org/text.asp?2006/24/1/76/19906


Dear Editor,

Septicaemia remains a significant cause of morbidity and mortality in the newborns, more so in the developing countries.[1] In India, the incidence of neonatal septiceamia has been reported to be 24/1000 live births.[2] Klebsiella spp. , Staphylococcus aureus, Pseudomonas, and  Salmonella More Details spp. have been reported as potential pathogens in neonatal septicaemias.[3] Various species of Salmonella which have been reported from neonatal infections are S. typhimurium, S. anatum, S. newport, S. seftenberg . [4]  Salmonellosis More Details is common in tropical countries and is found world wide, however S. paratyphi B causing neonatal septiceamia is rare. To the best of our knowledge S. paratyphi B causing neonatal septicaemia has not been reported so far.

A three-day-old neonate was brought to Command Hospital, Lucknow after a normal vaginal delivery at a private nursing home with a history of bluish discoloration of left lower limb, blisters and edema of the left thigh along with gangrenous changes of left toes. There was no history of any manipulations /trauma during delivery. On examination, the peripheral pulses of the left lower limb were absent and there were gangrenous changes of the left toes. The right lower limb was pink and had normal peripheral pulse. A provisional diagnosis of hypoxic ischaemic encephalopathy and hypovascularity of left lower limb was made. In the next two days the level of gangrene gradually extended to the thigh and left gluteal region, the popliteal and femoral pulses also disappeared after that. He was then diagnosed to have acute ischemia of left lower limb due to femoral block.

Blood culture yielded non-lactose fermenting colonies, which were gram negative and motile. The biochemical reactions were suggestive of S. paratyphi B. Further confirmation was done by agglutination with specific antisera and the organism was identified as S. paratyphi B, which was reconfirmed at Armed Forces Medical Colleges, Pune. The isolate was sensitive to amikacin, cefotaxime, tri methoprim and chloramphenicol. Subsequent urine cultures for the next three weeks yielded the same isolate . Stool culture was negative. The titres in the Widal test were inconclusive.

The patient was started on intravenous antibiotics. His general condition improved but his left lower limb had to be disarticulated from the hip joint. Blood cultures and urine cultures were repeated after effective antimicrobial therapy, and found to be sterile.

Salmonella infections may be divided into five categories- gastroenteritis, enteric fever, bacteraemia, localized infections and chronic carrier state. The most important localized infections outside the gastrointestinal tract are endovascular infections, osteomyelitis and meningitis. The frequency of transient bacteraemia in patients with Salmonella enterocolitis is less than 5%; however this percentage increases in children and persons with underlying disease.[5] Bacteraemia is a constant feature of enteric fever, which is usually caused by Salmonella , and its dissemination may lead to localized foci of infection especially when there is a preexisting abnormality, as in our patient who presented with acute ischaemia of left lower limb. Preexisting pathology makes the tissue vulnerable and provides a nidus for the bacteria to initiate a persistent infection. It is therefore a reminder to us that S. paratyphi B could be a cause of neonatal septicaemia in tropical countries making proper microbiological evaluation mandatory.

 
 ~ References Top

1.Khatua SP, Das AK, Chatterjee BD, Khatua S, Ghose B, Saha A. Neonatal septicaemia. Indian J Pediatr 1986 ; 53:509-14.  Back to cited text no. 1    
2.Report of National Neonatal Perinatal Database, National Neonatology Forum. 2000.   Back to cited text no. 2    
3. Chugh K, Aggarwal BB, Kaul VK, Arya SC. Bacteriological profile of Neonatal Septicaemia. Indian J Pediatr 1988; 55: 961-5.  Back to cited text no. 3    
4.Old DC. Salmonella, Chapter 21. In: Mackie and McCartney Practical Medical Microbiology , 14th edn. Churchill Livingstone: London; 1996. p. 385-402.  Back to cited text no. 4    
5.Mandel GL, Douglas RG, Bennet JE. Principles and Practice of Infectious diseases . 3rd edn. Churchill Livingstone Inc: London; 1990. p. 1700-10.  Back to cited text no. 5    




 

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