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CASE REPORT
Year : 2005  |  Volume : 23  |  Issue : 2  |  Page : 139-140
 

Candida tropicalis causing Prosthetic Valve Endocarditis


1 Department of Microbiology, Narayana Hrudayalaya, Bangalore, India
2 Department of Cardiac Surgery, Narayana Hrudayalaya, India

Correspondence Address:
T Mathew
Department of Microbiology, Narayana Hrudayalaya, Bangalore - 560 099, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0255-0857.16059

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 ~ Abstract 

The incidence of endocarditis produced by the so-called "opportunists" as a complication of prosthetic valve surgery is progressively increasing in frequency and gradually transforming the clinical picture habitually associated with this disease. Candida endocarditis is an unusual but severe complication caused by Candida albicans or other fungal species. This case and a review of the literature indicate that Candida endocarditis treated with amphotericin B and prosthetic valve replacement may recur months after treatment, and that late recurrent Candida endocarditis, which is difficult to diagnose and treat, may be best prevented by lifelong antifungal suppressive therapy.


Keywords: Candida, endocarditis, prosthetic valve


How to cite this article:
Nagaraja P A, Mathew T, Shetty D P. Candida tropicalis causing Prosthetic Valve Endocarditis. Indian J Med Microbiol 2005;23:139-40

How to cite this URL:
Nagaraja P A, Mathew T, Shetty D P. Candida tropicalis causing Prosthetic Valve Endocarditis. Indian J Med Microbiol [serial online] 2005 [cited 2019 Jun 24];23:139-40. Available from: http://www.ijmm.org/text.asp?2005/23/2/139/16059


Prosthetic valve endocarditis (PVE) is a frequently encountered complication of heart valve replacement surgery, accounting for 9.5-15 % of all endocarditis cases.[1] Fungi cause a small but significant proportion of PVE and contribute to 4-6% of all etiology.[2] We report a case of Candida endocarditis that was treated with Amphotericin B and prosthetic valve replacement.


 ~ Case Report Top


A 33-year-old female patient was admitted in April 2002 for complaints of easy fatigability, pre-syncope, swelling of both legs and occasional atypical chest pain. This patient was a known case of rheumatic heart disease (RHD), with severe mitral stenosis (MS), moderate aortic stenosis (AS) with moderate aortic regurgitation (AR), and moderate tricuspid stenosis (TS) with moderate pulmonary artery hypertension (PAH). The patient had undergone open mitral valvotomy (OMV), open aortic valvotomy (OAV) and open tricuspid valvotomy (OTV) in 1993. Preoperative echocardiagram showed severe mitral stenosis without MR, moderate AS with grade III AR and organic tricuspid disease. Adequate left ventricular (LV) function was noted. The patient underwent a mitral valve replacement using St Jude bi-leaflet prosthesis and aortic valve replacement (AVR) with a St. Jude valve (19 mm). Postoperatively, normal valve functions were noted and the patient was discharged on anticoagulants and other cardiac drugs.

The patient was readmitted a month later with complaints of persistent vomiting, giddiness and syncope. Echo showed impaired movement of the prosthetic mitral leaflets, grade II to III TR and a left ventricular ejection fraction of 35-40%. A stuck mitral prosthetic valve was diagnosed and thrombolytic therapy was attempted, which was unsuccessful. Patient underwent a tracheostomy for ventilatory assistance and subsequently the prosthetic mitral valve was replaced with Starr-Edwards Mitral valve prosthesis. Post-operatively, the patient needed haemodialysis for renal failure. Initially cultures of blood and respiratory secretions grew  Escherichia More Details coli , and urine specimens grew Candida species . The patient was discharged on oral Fluconazole as a prophylactic along with oral anticoagulants and other cardiac drugs.

The patient was readmitted 3 months later with complaints of general malaise, fever, nausea and vomiting. Echo showed vegetations on the prosthetic mitral valve. Blood cultures done on multiple occasions grew Candida species . A diagnosis of fungal prosthetic valve endocarditis was made. Based on the sensitivity, the patient was treated with Amphotericin B and Fluconazole. The patient was discharged on oral Fluconazole (200 mg/day). However, the patient failed to make any improvement and finally succumbed at her residence. The Candida isolate, grown from the blood cultures, on speciation using ID 32C (Mini-API, bioMιrieux, France) was identified as Candida tropicalis. The urine isolate was not available to confirm the identity. A final diagnosis of fungal infection of the prosthetic mitral valve caused by C. tropicalis was made.


 ~ Discussion Top


Candida species can cause clinical manifestations in various organs of the cardiovascular system, i.e., the pericardium, myocardium, and endocardium, with endocarditis being the best-known clinical entity. Endocarditis is seen primarily in intravenous drug users and in individuals with damaged native valves, especially in congenital heart disease or rheumatic valvular diseases, and in prosthetic heart valves.[3]

Medical cure of fungal prosthetic valve endocarditis (PVE) is rarely reported. Report of medical treatment of a patient with C. tropicalis PVE has been published. A huge tricuspid valvular vegetation was identified by two-dimensional transthoracic echocardiography. After a total of 2 g of amphotericin B, the patient continued with fluconazole daily with a follow-up of fifteen months. This report represents the first case of long-term survival of C. tropicalis PVE successfully managed without surgery.[4]

Candida infective endocarditis has a bad prognosis, specially in those patients not operated early; it develops in patients with predisposing factors, which in a published series were a previous infective endocarditis (four patients) and/or a prosthetic valve implantation -less than one year before; it has important morbidity with multiple embolic events, perivalvular involvement, valvular regurgitation and heart failure.[5]

The mortality due to Candida PVE is high, especially when PVE was complicated by congestive heart failure and persistent fungemia. For uncomplicated PVE, the mortality rate for patients receiving antifungal therapy alone (40%) was no worse than for those receiving combined medical and surgical therapy (33%).[6]

Thakur et. al. have reported treatment of Candida prosthetic valve endocarditis with a combination of Fluconazole and Amphotericin B.[7] A review of prosthetic valve endocarditis has shown that the overall mortality among the patients was 56% (88% among those with early onset - less than 2 months after the operation; and 40% among those with late onset - more than 2 months after the operation).[8] A higher mortality is also documented in those cases that develop endocarditis early after the surgery.

 
 ~ References Top

1.Wislon WR, Danielson GK, Giuliani ER, Geraci JE. Prosthetic valve endocarditis. Mayo Clin Proc 1982;57 :155-161  Back to cited text no. 1    
2.Karchmer AW, Gibbons GW. Infections of prosthetic heart valves and vascular grafts In: Bisno AL, Waldvogel FA eds. Infections associated with indwelling devices 2nd ed. Washington, DC: American Society for Microbiology; 1994. p. 213-249.  Back to cited text no. 2    
3.Joao I, Duarte J, Cotrim C, Rodrigues A, Martins C, Fazendas P, et al . Native valve endocarditis due to Pichia ohmeri. Heart Vessels 2002;16 :260-3.  Back to cited text no. 3    
4.Roel JE, Gamba A, Curone M, Pescio A, Bruno C, Finquelievich J. Successful medical treatment of Candida tropicalis in prosthetic valve endocarditis. Medicina (B Aires) 1998;58 :301-2.  Back to cited text no. 4  [PUBMED]  
5.Branco L, Pitta ML, Bernardes L, Galrinho A, Agapito AF, Ramos JM, et al . A review of infectious endocarditis due to Candida (Article in Portuguese). Rev Port Cardiol 1997;16 :967-74.  Back to cited text no. 5    
6.Nguyen MH, Nguyen ML, Yu VL, McMahon D, Keys TF, Amidi M. Candida Prosthetic Valve Endocarditis: Prospective study of six cases and review of the literature. Clin Infect Dis 1996;22 :262-7.  Back to cited text no. 6  [PUBMED]  
7.Thakur RK, Skelcy KM, Kahn RN, Cannon L, Cherukuri R. Successful treatment of Candida prosthetic valve endocarditis with a combination of fluconazole and Amphotericin B. Crit Care Med 1994;22 :712-4.  Back to cited text no. 7  [PUBMED]  
8.Wilson WR, Jaumin PM, Danielson GK, Giuliani ER, Washington JA II, Geraci JE. Prosthetic Valve Endocarditis. Ann Intern Med 1975;82 :751-6.  Back to cited text no. 8  [PUBMED]  



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