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 ORIGINAL ARTICLE
Year : 2003  |  Volume : 21  |  Issue : 3  |  Page : 172-178

Evaluation of in vitro and in vivo antibacterial activity of dobutamine hydrochloride


1 Department of Pharmaceutical Technology, Jadavpur University, Kolkota - 700 032, India
2 Gupta College of Pharmacy, Asansol - 713 301, India

Correspondence Address:
S G Dastidar
Department of Pharmaceutical Technology, Jadavpur University, Kolkota - 700 032
India
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Source of Support: None, Conflict of Interest: None


PMID: 17643013

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PURPOSE: To determine the in vitro and in vivo antibacterial activity of a cardiovascular drug dobutamine hydrochloride. METHODS: The minimum inhibitory concentration (MIC) of dobutamine was determined both by agar and broth dilution methods against 331 strains of bacteria from three gram positive and 13 gram negative genera. The antibacterial action of dobutamine was further tested in animal models. RESULTS: Dobutamine was seen to possess powerful inhibitory action (5-200mg/mL) against most test bacteria in in vitro studies. It was bacteriostatic in nature. In vivo studies showed that the drug offered significant protection (p<0.001) to mice challenged with a virulent bacterium. CONCLUSION: Dobutamine showed remarkable antibacterial property against several pathogenic bacteria. Its potential as an antibacterial agent may be confirmed after further pharmacological studies.






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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04