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 ORIGINAL ARTICLE
Year : 2003  |  Volume : 21  |  Issue : 2  |  Page : 98-101

Effect of azadirachta indica (neem) on the growth pattern of dermatophytes


1 Department of Microbiology, Rajah Muthiah Medical College, Annamalai University, Annamalainagar - 608 002, Tamil Nadu, India
2 Department of Microbiology, Dr.ALM PGIBMS, Taramani, Chennai - 600 113, India

Correspondence Address:
V Natarajan
Department of Microbiology, Rajah Muthiah Medical College, Annamalai University, Annamalainagar - 608 002, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


PMID: 17642990

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PURPOSE: To determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) for the extracts of the leaves and seeds of the plant Azadirachta indica against various dermatophytes. METHODS: Clinical isolates of dermatophytes(Trichophyton rubrum, Trichophyton mentagrophytes and Microsporum nanum) were treated with extracts of leaves and seeds of the plant Azadirachta indica (neem) for antifungal activity by in vitro tube dilution technique. RESULTS: The MIC of neem seed extracts was 31g/mL for all the dermatophytes tested. The neem seed extract at 15g/mL concentration (below MIC) was observed to be sufficient for distorting the growth pattern of the organisms tested. CONCLUSIONS: The changes in growth curve of the treated dermatophytes were found to be statistically significant with reference to the untreated fungi.






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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04