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CORRESPONDENCE
Year : 2003  |  Volume : 21  |  Issue : 2  |  Page : 144
 

Determination of baseline widal titres from Chandigarh


Department of Microbiology, Government Medical College and Hospital, Chandigarh - 160 031, India

Correspondence Address:
Department of Microbiology, Government Medical College and Hospital, Chandigarh - 160 031, India



How to cite this article:
Punia J N, Joshi R M, Gupta V, Arora R K. Determination of baseline widal titres from Chandigarh. Indian J Med Microbiol 2003;21:144


How to cite this URL:
Punia J N, Joshi R M, Gupta V, Arora R K. Determination of baseline widal titres from Chandigarh. Indian J Med Microbiol [serial online] 2003 [cited 2019 Jun 16];21:144. Available from: http://www.ijmm.org/text.asp?2003/21/2/144/7999


Dear Editor,
For diagnosing a case of enteric fever, Widal test is the second most widely used test after blood culture. Widal test using antigen suspensions appropriate to the diagnosis of the prevalent enteric fever agents has been used either to compare paired sera or to test a single serum taken on admission to see significant antibody levels.[1] In endemic countries like India, sera of a proportion of healthy individuals contain antibodies capable of reacting to a variable titre in Widal test due to previous stimuli. Therefore, baseline titres for anti-O and anti-H for  Salmonella More Details typhi and anti-H for  Salmonella More Details paratyphi A were evaluated and Widal test results were reported accordingly.
Two hundred and fifty five healthy volunteers were screened for  Salmonella More Details agglutinins using the Widal test. While, none of the serum samples showed an anti-O titre of 80, 87 (34.11%) had anti-O titres of 20. Whereas for S.typhi, 103 (40.39%) had anti-H titre of 20 and 4 (1.57%) had an anti-H titre of 160. Similarly for S.paratyphi A, 45 (17.64%) had anti-H titre of 20 only 2 (0.78%) had an anti-H titre of 160. Based on these findings, titres of 160 for anti-O and 320 for anti-H were considered diganostic for enteric fever in Chandigarh, North India. Similar diagnostic 'O' and 'H' titres have also been reported recently by others.[2]
In India, most patients present late to the hospital and require immediate diagnosis and specific treatment, and often a single sample has to be relied upon instead of paired serum samples. In that case, high titres of anti-O and anti-H should be considered presumptive for enteric fever. 

 ~ References Top

1.Collier L, Balows A, Sussman M. Bacterial Infections Vol-III. In: Topley and Wilsons' Microbiology and Microbial Infections. (Arnold Publishers, London) 1998,459-478.  Back to cited text no. 1    
2.Frimpong EH, Feglo P, Essel-Ahun M, Addy PA. Determination of diagnostic Widal titres in Kumasi, Ghana. West Afr J Med 2000;19(1):34-38.  Back to cited text no. 2    
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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04