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Year : 2003  |  Volume : 21  |  Issue : 1  |  Page : 64
 

Mycological and serological study of pulmonary aspergillosis in Central India


Department of Microbiology, JN Medical College, Aligarh Muslim University, Aligarh - 202 002, Uttar Pradesh, India

Correspondence Address:
Department of Microbiology, JN Medical College, Aligarh Muslim University, Aligarh - 202 002, Uttar Pradesh, India



How to cite this article:
Shahid M, Malik A. Mycological and serological study of pulmonary aspergillosis in Central India. Indian J Med Microbiol 2003;21:64


How to cite this URL:
Shahid M, Malik A. Mycological and serological study of pulmonary aspergillosis in Central India. Indian J Med Microbiol [serial online] 2003 [cited 2019 Jun 27];21:64. Available from: http://www.ijmm.org/text.asp?2003/21/1/64/8325


Dear Editor,
I want to congratulate Dr. Kurhade and colleagues for sharing the data on Aspergillosis from Central part of India.[1] Although, the work is carefully and critically done, some clarifications from the authors are needed.
The purpose of the above mentioned study was to show the prevalence of Aspergillosis in chronic pulmonary infections, therefore, the authors should have done the study in chronic lung disease patients rather than patients suspected of having Aspergillosis. It is surprising to see that authors have not cited the related Indian literature on prevalence of Aspergillosis, one of which was published in recent issue of IJMM.[2] Similarly, authors have not cited the latest literature regarding the association of Aspergillosis with chronic lung disease from Indian literature.
For serological study, only the antigens of A. fumigatus and A. niger were prepared. Why was the antigen of A. flavus not prepared although A. flavus was isolated in their study and it is a well documented cause of Aspergillosis?[2],[3] For preparing the antigens, authors should have ideally used multiple strains of each species as the antigenic variations of Aspergillus has already been reported.[4] In order to compensate for isolate variations, antigens derived from multiple strains of Aspergillus species have been recommended for detection of antibodies in patients' sera.[5]
Authors have performed only immunodiffusion test for serodiagnosis of Aspergillosis, however, it is a well known fact that mainly reaginic antibodies are found in asthmatic patients.[2] As there were 11 patients of asthma in the study, authors might have missed few cases by performing serodiagnosis only by ID.
The statement "28 sera reacted with A. fumigatus antigen while only 3 reacted with A. niger antigen" also creates confusion. It is not mentioned whether the cross reaction between A. fumigatus and A. niger was present however, I suspect that such was the case because the data showed by the authors indicates that only 29 cases were serologically positive.
Though the data of antifungal susceptibility is well tabulated, correction is needed in the last line of results (MIC range of itraconazole should be 0.125 - 1g/mL instead of 0.5 - 2g/mL). Similarly MIC ranges of amphotericin B and fluconazole needed attention.  

 ~ References Top

1.Kurhade AM, Deshmukh JM, Fule RP, Chande C, Akulwar S. Mycological and serological study of pulmonary aspergillosis in central India. Indian J Med Microbiol 2002;20:141-144.  Back to cited text no. 1    
2.Shahid M, Malik A, Bhargava R. Prevalence of Aspergillosis in chronic lung diseases. Indian J Med Microbiology 2001;19:201-205.  Back to cited text no. 2    
3.Villar TG, Cortez Pimental J, Freitas M, Costa E. The tumour like forms of Aspergillosis of the lung (Pulmonary Aspergilloma). Thorax 1962;17:22-38.  Back to cited text no. 3    
4.Malo JL, Paquin R, Longbottom JL. Prevalence of precipitating antibodies to different extracts of Aspergillus fumigatus in North American asthmatic population. Clin Allergy 1981;11:333-341.  Back to cited text no. 4    
5.Wallenbeck I, Aukrust L, Einarsson R. Antigenic variability of different strains of Aspergillus fumigatus. Int Achs Allergy appl Immun 1984;73:166-172.  Back to cited text no. 5    
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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04