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CORRESPONDENCE
Year : 2002  |  Volume : 20  |  Issue : 4  |  Page : 228
 

Prevalence of Drug Resistance among M.tuberculosis Isolates in Indore (M.P.)


Department of Microbiology, Choithram Hospital and Research Centre, Manik Bagh Road, Indore - 452 016, MP, India

Correspondence Address:
Department of Microbiology, Choithram Hospital and Research Centre, Manik Bagh Road, Indore - 452 016, MP, India



How to cite this article:
Hemvani N, Chitnis D S. Prevalence of Drug Resistance among M.tuberculosis Isolates in Indore (M.P.). Indian J Med Microbiol 2002;20:228


How to cite this URL:
Hemvani N, Chitnis D S. Prevalence of Drug Resistance among M.tuberculosis Isolates in Indore (M.P.). Indian J Med Microbiol [serial online] 2002 [cited 2019 Jun 17];20:228. Available from: http://www.ijmm.org/text.asp?2002/20/4/228/6967


Dear Editor,
The article “Drug Susceptibility Profiles of Mycobacterium tuberculosis isolates at Jaipur” by Malhotra et al, which appeared in Indian Journal of Medical Microbiology 2002;20:76-78 gives valuable data on the drug resistance in M.tuberculosis in Jaipur. The authors seem to have missed to mention our data[1] on 1426 isolates of M.tuberculosis in Central India during 1987-1998. We wish to share our subsequent and recent observations on 374 isolates during 2000-2001. The isolates were from cases of pulmonary tuberculosis not responding satisfactorily to the primary drugs. The drug susceptibility was carried out by method of critical concentration and critical proportion using LJ slants as described earlier.[1]
Prevalence of resistance to isoniazid (INH) and rifampicin was 65.2% and 23.3% respectively while 16% were resistant to both INH and rifampicin which is closer to 24.3% acquired resistance reported by Malhotra et al in the present article. Resistance to streptomycin and kanamycin was 45.5% and 28.9% respectively while 38.5% and 44.4% were resistant to ethambutol and ethionamide respectively. Resistance for pyrazinamide has remained high in our study (57.5%) while thiacetazone and PAS have low resistance (5 and 8.6% respectively).
The most important observation appears to be increase in the resistance for ciprofloxacin. Till 1999 the ciprofloxacin resistance was 3.6% in our study[1] and in 2000 it was 6.2% which increased to 12% in the year 2001. Further, it needs to be mentioned that ciprofloxacin is commonly prescribed in our region to treat cases of pulmonary tuberculosis responding poorly to primary regimen. It is feared that ciprofloxacin resistance may grow very high among Mycobacterium spp. as witnessed for other bacterial pathogens in hospital practice and hence it should be used discriminately in treating tuberculosis. 

 ~ References Top

1.Hemvani N, Chitnis DS, Bhatia GC, Sharma N. Drug Resistance among Tubercle Bacilli from Pulmonary Tuberculosis Cases in Central India, Ind J Med Sci 2001; 55:382-392.  Back to cited text no. 1    
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