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Year : 2001  |  Volume : 19  |  Issue : 4  |  Page : 232
 

Antibiotic resistance in pseudomonas aeruginosa strains isolated from various clinical specimens - A retrospective study


Department of Microbiology, GMCH, Chandigarh - 160 047, India

Correspondence Address:
Department of Microbiology, GMCH, Chandigarh - 160 047, India



How to cite this article:
Mehta M, Punia J N, Joshi R M. Antibiotic resistance in pseudomonas aeruginosa strains isolated from various clinical specimens - A retrospective study. Indian J Med Microbiol 2001;19:232


How to cite this URL:
Mehta M, Punia J N, Joshi R M. Antibiotic resistance in pseudomonas aeruginosa strains isolated from various clinical specimens - A retrospective study. Indian J Med Microbiol [serial online] 2001 [cited 2020 Jul 3];19:232. Available from: http://www.ijmm.org/text.asp?2001/19/4/232/8202


Dear Editor,
This is the report of antibiogram of 381 clinical isolates of Pseudomonas aeruginosa from blood, pus and body fluids of patients seeking treatment at Govt. Medical College & Hospital, Chandigarh from April 1997 to March, 1999. The isolates were identified as Pseudomonas aeruginosa by standard procedures[1],[2] and their antibiogram was studied for amikacin, ciprofloxacin, piperacillin, gentamicin and ceftazidime.
The isolates were from pus (n=292,) blood (n=81) and body fluids (n=8) ; [Male: 227, Female: 154].Whereas resistance was found in 11%, 12% and 13.5% of blood isolates against amikacin, ciprofloxacin and piperacillin respectively, it was only 10% for each of these drugs from pus isolates. Resistance against gentamicin was encountered in 28% of pus and 30% of blood isolates. Resistance to ceftazidime was seen in 16% of pus and 20% of blood isolates. The number (n=8) of isolates from body fluids was too small to comment on.
Many antibiotics inhibit 'in vitro' growth of Pseudomonas aeruginosa, but only a minority of these show useful activity at 'in vivo' therapeutic levels. A recent study on antimicrobial resistance among urinary isolates of Pseudomonas aeruginosa in Europe[3] showed best results for the carbapenems (susceptibility 89%), piperacillin (84%), and amikacin and ticarcillin (80% each). In another study 2.6%, 9.1%, 9.6%, 45.7% 39.9% and 51% of Pseudomonas aeruginosa isolates were found to be resistant to piperacillin, ceftazidime, imipenem, ciprofloxacin, amikacin and gentamicin respectively.[4] We, in our study, found amikacin, ciprofloxacin and piperacillin to be the most effective anti-pseudomonal agents. 

 ~ References Top

1.Mackie & McCartney. Practical Medical Microbiology, 14th Edition Churchill Livingstone Edinburg (1989), 491-504.  Back to cited text no. 1    
2.Cowan & Steel. Manual for the identification of Medical Bacteria 3rd Edition. G I Barrow & Felthan R K A Cambridge Uni-Press; 1993: 113-116   Back to cited text no. 2    
3.Fluit AC, Jones ME, Schmitz FJ, Acar J, Gupta R, Verhoef J. Antimicrobial resistance among urinary tract infection (UTI) isolates in Europe: results from the SENTRY ntimicrobial Surveillance Program 1997. Antonie van Leeuwenhoek 2000; 77(2):147-152.  Back to cited text no. 3    
4.Muller-Premru M, Gubina M. Serotype, antimicrobial susceptibility and clone distribution of Pseudomonas aeruginosa in a University hospital. Zentralblatt fur Bakteriologie 2000; 289(8): 857-867.  Back to cited text no. 4    
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2004 - Indian Journal of Medical Microbiology
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