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CORRESPONDENCE
Year : 2001  |  Volume : 19  |  Issue : 2  |  Page : 32
 

Serological evidence in suspected cases of leptospirosis in and around Manipal


PG Shivananda, Department of Microbiology, Kasturba Medical College, Manipal - 576 119, Karnataka, India

Correspondence Address:
PG Shivananda, Department of Microbiology, Kasturba Medical College, Manipal - 576 119, Karnataka, India



How to cite this article:
Rao P S, Sridhar V S. Serological evidence in suspected cases of leptospirosis in and around Manipal. Indian J Med Microbiol 2001;19:32


How to cite this URL:
Rao P S, Sridhar V S. Serological evidence in suspected cases of leptospirosis in and around Manipal. Indian J Med Microbiol [serial online] 2001 [cited 2019 Aug 22];19:32. Available from: http://www.ijmm.org/text.asp?2001/19/2/32/6933


Dear Editor,
Leptospirosis is an important public health problem all over the world. In India cases have been reported as early as 1915, especially from Andamans, Calcutta, Assam and Bombay.[1] There are reports of several outbreaks in India.[2] This study was undertaken to correlate clinical diagnosis of Leptospirosis with serological evidence. The serological tests used in this study were Enzyme linked immunosorbent assay (ELISA) and Indirect haemagglutination (IHA) for IgM antibodies against Leptospira.
A total of 401 blood samples, collected from suspected cases of Leptospirosis admitted to Kasturba Medical College and hospital (KMCH) Manipal, were processed for serological evidence by ELISA and IHA, ELISA was performed using IgM ELISA kit from Virion Serion from Germany. IHA was performed using Leptospira IHA kit from MRL Diagnostics. IHA test used 1% human 'O' group erythrocytes sensitized by Leptospiral antigens. Culture was positive in few cases.
Out of 401 cases of suspected Leptospirosis 108 (26.93%) were Positive by ELISA or IHA and out of 107 ELISA positive samples 106 were positive by IHA also [Table - 1].
The clinical symptoms of serologically positive cases of leptospirosis is shown in [Table - 2].
Leptospirosis is a reemerging infectious disease in our country. Incidence has increased in recent times.[3] South Canara and Udupi districts have good rainfall and agriculture as occupation, enhancing the growth of rodent population. Higher incidence has been observed during wet season. [4] In the present study higher incidence was observed during end of rainfall. In this study, of the total 108 positive cases common presenting symptom was fever (100%), fever with jaundice (57.4%) and renal failure (54.62%). Serological tests for Leptospirosis will help the clinicians to confirm the diagnosis and start the treatment at an earliest stage. 

 ~ References Top

1.Dasgupta BM , Chopra RN. The occurrence of Weil's disease in India. Indian Medical Gazette 1937;72:610-612.  Back to cited text no. 1    
2.Madhusudhan SN, Bhargava SR. Serological Survey of Leptospirosis in and around Bangalore. Ind J Pathol Microbiol 1988;32:60-64.  Back to cited text no. 2    
3.Sehgal SC, Mushekar MV, Suganan AP. Outbreak of Leptospirosis with pulmonary involvement in North Andaman. Ind J Med Res 1944;102:9-12.  Back to cited text no. 3    
4.Peterspleenman in Harrisons's Principles of Internal medicine. Page 1036, Vol 1. 14 th edition, 1988; McGraw Hill, USA.  Back to cited text no. 4    
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2004 - Indian Journal of Medical Microbiology
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