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Year : 2000  |  Volume : 18  |  Issue : 2  |  Page : 62-65

Studies of elimination of R-plasmids by triprolidine

Department of Microbiology, Calcutta National Medical College, Calcutta

Correspondence Address:
K Roy
Department of Microbiology, Calcutta National Medical College, Calcutta

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Source of Support: None, Conflict of Interest: None

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ABSTRACT: We have reported recently on the wide spectrum of antibacterial activity of triprolidine, commonly marketed by the trade name actidil (R). Triprolidine, a broad spectrum antibacterial agent produces mutants under experimental selection procedures and these mutants develop cross-resistance to several other antibiotics. In this study of curing anti-plasmid effect on multiply antibiotic and triprolidine resistant bacterial, it was observed that elimination of R Plasmids was facilitated by the choice of optimal concentration of triprolidine. Significant elimination of single and combined antibiotic resistance occurred in S. aureus, E.coli and V.cholerae.

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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04