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Year : 1999  |  Volume : 17  |  Issue : 2  |  Page : 81-84

Adaptive acid tolerance in klebsiella pneumoniae


Department of Microbiology, Punjab University, Chandigarh 160 014

Correspondence Address:
P Aghi
Department of Microbiology, Punjab University, Chandigarh 160 014

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Source of Support: None, Conflict of Interest: None


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ABSTRACT: Klebsiella pneumoniae acquired an increased acid tolerance during exponential growth upon exposure to sublethal acid stress, a response designated as acid tolerance response (ATR). Maximal acid resistance was seen when the organism was exposed to pH 5.0 (pre acid shock) prior to challenge at pH 3.5 (acid shock). In the presence of organic acids the organism was also able to survive the acidic stress. These results indicate that ATR mechanism is operative in this selected strain of K.pneumoniae (CH). It was observed that protein synthesis is essential for the development of this mechanism. the significance of development of ATR in this pathogen is discussed.






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2004 - Indian Journal of Medical Microbiology
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