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Year : 1998  |  Volume : 16  |  Issue : 4  |  Page : 154-157

Testing pooled sera for HCV antibody : an economic consideration


Department of clinical virology Christian Medical College Hospital, Vellore 632 004

Correspondence Address:
S Christopher
Department of clinical virology Christian Medical College Hospital, Vellore 632 004

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Source of Support: None, Conflict of Interest: None


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ABSTRACT: The need for the screening of blood donors for hepatitis C virus antibody (anti-HCV) is increasingly being recognised in developing countries. However, it has not yet become the standard practice due to the high cost of anti-HCV testing. In an attempt to reduce the cost of testing, we evaluated the reliability of testing pooled sera. A total of twenty serum pools each containing two, three, five and ten sera were tested using a second generation anti-HCV test kit (Abbott Diagnostics, North Chicago, III). Each serum pool contained one anti-HCV positive serum of low, medium or high antibody content. All pools of two sera tested positive for anti-HCV, whereas pools of 3 or more sera were found to be unsatisfactory. This data showed pools of two sera can be tested reliably, and this approach would significantly reduce the cost of anti-HCV testing, without compromising on the sensitivity.






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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

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