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Year : 1995  |  Volume : 13  |  Issue : 1  |  Page : 41-44

Immunization of hospital staff by recombinant hepatitis B vaccine


Department of Gastroenterology The Nizam's Institute of Medical Sciences, Hyderabad, Andhra Pradesh, India

Correspondence Address:
N Joshi
Department of Gastroenterology The Nizam's Institute of Medical Sciences, Hyderabad, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


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ABSTRACT: A total number of 247 hospital staff working high risk department of the Nizam's Institute of Medical Sciences were vaccinated with recombinant Hepatitis B vaccine (Engerix V, Smith & Kline, Germany). The sero conversion was assessed by testing antibody to HBsAg in 147 subjects after each dose and in another 100 subjects a month after third dose. The antibody positivity was 12 percent, 15 percent and 98 percent after the first, second and third doses, respectively. the range of antibody levels was 14.7-82.5 mlU/ml, 10.4-185.5 mlU/ml and 27.1-807.2 mlU/ml respectively in the 3 doses. In 72 persons the third dose was delayed by 2-8 months due to various reasons, yet the protective antibodies were observed in 97 percent of the subjects. The vaccine was well accepted with minimal reactions. It is concluded that the recombinant HBV vaccine is effective, safe, highly immunogenic and well tolerated.






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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04