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Year : 1995  |  Volume : 13  |  Issue : 1  |  Page : 15-17

Evaluation of an enzyme immunoassay for detection of immunoglobulin M to treponema pallidum in syphilis


1 Department of Microbiology, University College of Medical Sciences and G.T.B Hospital Shahdara, Delhi

Correspondence Address:
M Mahajan
Department of Microbiology, University College of Medical Sciences and G.T.B Hospital Shahdara, Delhi

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Source of Support: None, Conflict of Interest: None


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ABSTRACT: A new enzyme immunoassay (Imzyme M-TP, Fujirebiu, Japan) for detecting IgM antibodies against Treponema pallidum was evaluated. Serum samples from 126 patients, 102 with various stages of untreated syphilis, 12 with treated syphilis and 12 from antenatal cases, were investigated. All sera were also examined by Veneral Disease Research Laboratory (VDRL) test and Treponema Pallidum Haemagglutination Assay (TPHA). In all diagnostic groups of syphilis the reactivity of IgM-EIA was similar to that of VDRL and TPHA except in latent syphilis. False positive IgM-EIA results were not found in 12 antenatal cases who gave false positive VDRL reactions. This indicated that IgM-EIA was very specific. All serum samples from treated patients were non reactive in the IgM-EIA 6 months after treatment. In conclusion, IgM-ELA can be a useful test in early stages of syphilis, for screening of congenital syphilis and for treatment monitoring.






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2004 - Indian Journal of Medical Microbiology
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