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Year : 1993  |  Volume : 11  |  Issue : 3  |  Page : 187-190

Role Of Mycobacterium Leprae Particle Agglutination (MLPA) Test In The Diagnosis Of Leprosy.



Correspondence Address:
Deepjyoti V Gadre


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Serodiagnosis of leprosy is useful for clinical practice and epidemiological studies. The natural phenolic glycolipid-I (PGL-I) antigen which is routinely used for serological tests in leprosy is extremely hydrophobic in nature. In this study, mycobacterium Leprae practical Agglutination (MLPA) test was performed by using the Natural Trisaccharide phenyl propionate/Bovine serum Albumin (NTP-BSA) antigen coated on gelatin particles for detection of anti-PGL-I. The slit smears from 104 cases of clinically diagnosed ziehl Neelsen’s staining form the presence of Mycobacterium leprae. 32/104 cases were multibacillary. The positivity rates of MLPA were 78% in Lepromatous and 22% in tuberculoid cases, making it reliable to detect-anti PGL-I antibodies in multibacillary cases. Higher titers were observed in new untreated lepromatous cases as compared to old treated lepromatous cases. MLPA was found to be a simple, rapid test and could be helpful in monitoring chemotherapy.






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