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Year : 1993  |  Volume : 11  |  Issue : 3  |  Page : 164-169

HLA B27 - Risk Factor In Families Of Ankylosing Spondylitis In South India.



Correspondence Address:
A. N Chandrasekaran


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The association between Class I HLA antigens and Ankylosing spondylitias (A.S) among 42 first degree relatives of 20 AS probands and 40 unrelated A.S patients of South India was studied in Government General Hospital, Madras. 50 healthy persons served as controls. HLA B 27 and CW2 were not found in healthy controls whereas 85% of unrelated AS Patients and 92.3% of affected relatives of A.S probands were positive for B27. CW2 was present in 57.5% and 30.7% among unrelated patients and affected relatives respectively. Significant positive association (p<0.001) was observed with B27. CW6 was negatively associated with the disease. (P<0.1) No specific HLA marker could be identified among B27 negative A.S Patients. The incidence of A.S was more (34.2%) among B27 positive probands than among those of B27 negative probands (14.3%).






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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04