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Year : 1993  |  Volume : 11  |  Issue : 1  |  Page : 51-55

Pathogenesis Of Anaemia In Malaria Infection



Correspondence Address:
M. L Dubey


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Source of Support: None, Conflict of Interest: None


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Malaria continues to be a major public health problem in India. Anaemia, a major complication of P. falciparum infection is an important cause of morbidity and at times mortality in malaria. Pathogenesis of anaemia in malaria is not well understood. It is generally recognized that the degree of anaemia in P. Falciparum infection is usually much more than expected from the level of parasitaemia. The hypotheses puts forward like “mechanical disruption” and “immune-haemolysis” due to autoantibodies do not explain all the aspects of anaemia. Recent studies indicate that oxidant stress due to increased production of reactive oxygen species and the compromisation of antioxidant system of red blood cells may have an important role in pathogenesis of anaemia in malaria.






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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04