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Year : 1993  |  Volume : 11  |  Issue : 1  |  Page : 36-42

Urease Production, Klebocin Sensitivity And Antibiotic Resistance Of Klebsiella, Organisms

Correspondence Address:
R. R Rao

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Source of Support: None, Conflict of Interest: None

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A total of 196 strains of Klebsiella isolated from clinical specimens were studies for their urease activity, Klebocin sensitivity and antibiotic resistance patterns. It was observed that 67.3% of the total isolates were urease positive. Klebocin sensitivity typing of the isolates showed that 85.2% strains were typable and they could be grouped into 30 Klebocin types. The commonest types were 244, 311, 111, 112, 141, 121, 224, 122, 113, 142. Urease positive strains were more typable (93.9%) compared to urease negative strains (67.1%). Majority of the urease positive strains belonged to the first 10 major klebocin types. The Klebocin producer 153 inhibited 76% of the total typable strains; while the other klebocin producers were less active (40% to 50%). Urease producing strains were more sensitive to all to Klebocin producers compared to Urease negative strains ( < 0.05). Majority of the isolates were resistant to Ampicillin (86.5%) followed by other antibiotics like Streptomycin (66.5%), Co-trimaxamzole (64%.5%), Chloramphenicol (62%), Kanamycin (59.5%) and Gentamycin (36%). A significant difference in the incidence of the resistance to antibiotics like Ampicllin, Tetracycline, chloramphenicol and kanamycin was noted when majority of the other Klebocin types and non typable strains were compared. Further the incidence of the multiple antibiotics resistance was significantly more in typable strains than in non-typable strains. The study shows that there may be a common plasmid or plasmids mediating the urease production, klebocin sensitivity and antibiotic resistance since more number of urease positive strains are typable and incidence of multi drug resistance is more among them.


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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04