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Year : 1992  |  Volume : 10  |  Issue : 2  |  Page : 94-100

Significance Of IgG Antibody Of Mycobacterium Tuberculosis Antigen 5 In Cerebrospinal Fluid Of Patients With Chronic Meningitis



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A Mathai


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In a prospective study, an enzyme - linked immunosorbent assay (ELISA), for the detection of lgG antibody of Mycobacterium tuberculosis antigen 5 was used on cerebrospinal fluid (CSF) specimens from fifty patients with a clinical diagnosis of chronic meningitis. CSF from ten culture proven patients with tuberculous meningitis (TBM) and CSFs from fifty patients with non-tuberculous neurological diseases were selected as positive and negative controls. IgG antibody to antigen5 was demonstrated in significant titers (80-640) in CSFs of positive controls. In the negative controls, ELISA gave of negative result at 1 in 80. In nine out of fifty patients with chronic meningitis, the ELISA gave positive results and the antibody titers in CSFs in these nine patients ranged between 80-640. Anti-tuberculosis chemotherapy was instituted in these nine patients for four weeks during their hospital stay. At the time of follow-up, six out of nine patients showed improvement in their clinical status. The remaining three patients expired during the hospital stay and the diagnosis of TBM was confirmed at autopsy. The result of this study emphasizes the potential application of ELISA either to establish a tuberculous a etiology of its exclusion in patients with chronic meningitis.






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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

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