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Year : 1992  |  Volume : 10  |  Issue : 2  |  Page : 107-113

R-Factor Mediated Multiple Drug Resistance In S.Typhi Strains Isolated For Seven Years


Correspondence Address:
Vinod Kaul


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Two hundred and two strains of Salmonella typhi isolated from pediatric patients, during the years 1982 to 88, were studied for drug resistance and transferable R-plasmids. Of these, 185 (91.5 per cent) were drug resistant, 31 (16.7 per cent) were multiple drug resistant and 23 (12.4 per cent) were resistant to chloramphenicol. The minimal inhibitory concentration for chloramphenicol ranged between 64 to 256 mcg/ml. The isolation of multiple drug resistant strains increased significantly from years 1982 to ’88, Ampicillin and tetracycline resistant strains increased two fold, whereas, chloramphenicol and co-trimoxazole resistant strains increased to 4.94 and 3.83 fold respectively. The most common resistance pattern among multiple drug resistant strains was ampicillin, tetracycline, sulfamethoxazole plasmids were more prevalent in multi drug resistant strains. Furthermore, transferability of R-plasmids from multi drug resistant intestinal Escherichia coli to sensitive S. typhi was also observed. The frequency of transfer was low with S. typhi (between 1 X 10 6 to 5.6 X 10-7) as compared to E. coli (1.1 to 10-2 to 3.6 X 10-3).






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2004 - Indian Journal of Medical Microbiology
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