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Year : 1992  |  Volume : 10  |  Issue : 1  |  Page : 3-15

Current Status Of H. Influenzae Type B Vaccines


Correspondence Address:
Mathuram Santosham


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Source of Support: None, Conflict of Interest: None


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Haemophilus influenzae type b (Hib) is the leading cause of meningitis in children below 5 years of age. Majority of cases of Hib occur in infants below 2 years of age. Until recently the only vaccine available against this disease contained the pure polysaccharide (PRP) of (Hib-PRP Vaccine). The Hib-PRP vaccine was demonstrated to be efficacious in infants above 18 months of age but not below that age. This product was licensed for routine use in the U.S.A. for children aged 24 months or more. Recently a hyper immune globulin termed bacterial polysaccharide immune globulin (BPIG) was prepared by immunizing adult donors with Hib-PRP, meningococcal and pneumococcal vaccines. BPIG has been demonstrated to prevent Hib infections when it is administered to infants at 4-month intervals. However, BPIG has not been licensed for routine use in the U.S.A.A number of new Hib conjugate vaccines have also been developed in the last few years by covalently linking the Hib-PRP to different carrier proteins. Four different Hib conjugate vaccines have undergone clinical trials in the U.S.A. Two of these vaccines, HbOC (Hib capsular oligosaccharide linked to CRM 197) and Hib-OMPC (Hib capsular polysaccharide linked to Neisseria meningitides outer membrane protein complex) have been demonstrated to protect infants aged 2 months or more from Hib disease. Both HbOC and Hib-OMPC are currently licensed for routine use in the U.S.A. The widespread use of these vaccines should have a substantial impact in reducing morbidity and mortality from Hib disease.






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2004 - Indian Journal of Medical Microbiology
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Online since April 2001, new site since 1st August '04