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Year : 1992  |  Volume : 10  |  Issue : 1  |  Page : 23-28

Development Of A Simple Burn Mouse Model And Its Evaluation To Study The Efficacy Of Soframycin Against Pseudomonas Aeruginosa Infected Burns

Correspondence Address:
Rauf Latif

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Source of Support: None, Conflict of Interest: None

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To study burns in animal model, we report here construction of a simple modified burning device, which produces standard scald burns in mice or rats. The injury is inflicted by immersion of the area to be burned in boiling water while the animal is held in a protective template, which limits the area of exposure. Our study using this device has shown that large number of animals can be burned in a reasonably short time. Further work on the efficacy of soframycin as a topical applicant against Pseudomonas aeruginosa in such a model has shown that the infected but treated (G-III) group of mice showed a low mortality of only 8.5% when compared to the mortality of 66% seen in the untreated but infected group (Gll). Our findings of death in the control group (Gl) certainly warrants study on the role of other organisms in burns. This device seem to be an ideal choice to study the efficacy of topical antibiotics and burn metabolisms in animals.


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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04