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Year : 1992  |  Volume : 10  |  Issue : 1  |  Page : 16-22

Human Papilloma Virus In Normal, Preneoplastic And Neoplastic Epithelia Of The Cervix Uteri



Correspondence Address:
K Udayasankar


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Identification of Human papilloma virus infection of the genital tract was made on patients attending the Gynaecology O.P.. Cytomorphology and Southern blot hybridization were compared for their ability to detect HPV. Separate cervico vaginal smears from 100 patients were subjected to Pap smear study. Concurrent punch biopsies from fifty patients and 12 controls were tested for HPV types 6/11, 16, 18, and 16/18 by Southern blot hybridization. While 48.4% (30/62) of them were hybridization positive, 80.6% (50/62) showed positivity for HPV associated cytopathology. HPV 16 was found in all grades of cervical lesions (80%). HPV 6/11 was present in initial grades of cervical lesions and HPV 18 in higher grades of lesion. A correlation of 83% was observed between DNA hybridization and cytomorphology in the detection of cervical neoplasia.






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2004 - Indian Journal of Medical Microbiology
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