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Year : 1990  |  Volume : 8  |  Issue : 4  |  Page : 121-127

Epstein-Barr Virus And Rheumatoid Arthritis-Associated Nuclear Antigen (RANA) In Rheumatoid Arthritis : A Correlative Study



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R Latif


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In an attempt to correlate Epstein-Barr Virus and rheumatoid arthritis-associated nuclear antigen (RANA) 87 rheumatoid arthritis (RA), 66 connective tissue disorder and 76 controls were analyzed for antibodies to RANA and antibodies of EBV. Besides screening them for rheumatoid factor by conventional Rose-Waaler and Latex methods, anti-RANA and anti-EBV were screened by an in house agar gel diffusion and ELISA methods respectively. Further correlation was also done by radioimmunoprecipitation. Anti-RANA prevalence was found to be 68.1% in RA when compared to 39.3% in other connective tissue disease and 22.3% in normals, Rheumatoid arthritis patients also showed a higher positivity of Anti EBV (75.8%) when compared to 50% in other arthritis and 47.3% in controls. The breakup analysis has shown a good correlation of anti-RANA and anti-EBV in seropositive group than in seronagative (P < 0.01). Rheumatoid factor positivity has also seen to be dependent on anti-RANA and anti-EBV positivity. Radioimmunoprecipitation study has also revealed the cross-reactivity of RANA and EBV. The above parameter has reasonably RANA as an EBV component.






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2004 - Indian Journal of Medical Microbiology
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