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Year : 1990  |  Volume : 8  |  Issue : 2  |  Page : 53-59

Immunological Reactivity Of Lungs : Immunoglobulin Secreting Cells In Pneumocystis Carinii Infected Rates.



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H Vohra


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Experimental pneumocystis carinii infection was induced in young rats by injecting hydrocortisone and feeding low protein diet. The number of immunoglobulin secreting cells were checked by reverse plaque assay in the bronchoalveolar lavage from infected animals weekly. It was seen that IgM and IgG secreting cells decreased in number even before P. carinii cysts were detected in the lavage. IgA secreting cells decreased in number till 5th week of infection and later increased in the experimentally infected animals. In the group of animals injected with steroids alone there was a steady decline in immunoglobulin secreting cells till the completion of study. The role of raised IgA levels during peak parasite load discussed.






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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

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