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Year : 1989  |  Volume : 7  |  Issue : 4  |  Page : 164-169

Augmentin (Amoxycillin + Clavulanic Acid) As An Antibeta-Lactamase Antibiotic-An In Vitro Study



Correspondence Address:
K Vandana


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The antibacterial activity of Augmentin (Amoxycillin and Clavulanic acid) was determined on 100 bacterial strains isolated from the pathological specimens. A significant difference in the sensitivity pattern between Augmentin and the other commonly used B-lactam antibiotics was noted with respect to the strains of Staphylococcus aureus, Escherichia coli and Klebsiella spp. The Minimum inhibitory. Concentration (MIC) of Augmentin for S. aureus was lower than that for E. coli and Klebsiella sp. However the MIC values are more than one quarter to half the concentration of the clavulanic acid which can be obtained in the serum with usual recommended dosage. It was also observed that the concentration of clavulanic acid in the discs employed for the disc diffusion test was 5 times more than the peak serum levels achieved with usual dosage. Hence our study concludes that though Augmentin shows significant in vitro activity against some commonly encountered bacteria, which does not correlate with the peak serum values in vivo. Further studies using having lower concentration of clavulanic acid are needed.






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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04