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Year : 1989  |  Volume : 7  |  Issue : 3  |  Page : 105-109

Comparative Study Of Potency Assay Of Diphtheria And Tetanus Components By Antibody Induction Method In Various Laboratory Animals



Correspondence Address:
B Singh


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Breeding, care and management of large colony of guinea pigs suitable for performing potency testing is expensive as well as difficult to maintain. Moreover there is acute shortage of these animals in the country. In the present study effort has been made to find the suitability of different Breeding, care and management of large colony of guinea pigs suitable for performing potency testing is expensive as well as difficult to maintain. Moreover there is acute shortage of these animals in the country. In the present study effort has been made to find the suitability of different laboratory animals like mice, rats and hamster vis-a-vis quinea pigs for performing the potency of diphtheria and tetanus components by antibody titration method of adsorbed diphtheria tetanus vaccine (DT) and diphtheria tetanus pertossis vaccine (DPT). The results show that rats and mice were equally suitable for potency assay of diphtheria and tetanus component. Hamsters were not found to be suitable for assaying the potency of diphtheria components. Marked adjuvant effect of pertussis component was observed while performing the potency of tetanus component in rats. Comparative results of potency as obtained in different laboratory animals have been presented and discussed.






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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04