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| Year : 1986 | Volume
: 4
| Issue : 3 | Page : 199-204 |
Mechanism Of Enhancement Of Virulence Of Entamoeba Histolytica In Hosts Under Heat Stress
Imtiaz Ahmad, P.C Sen
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Correspondence Address:
Imtiaz Ahmad
Using seven strains of entamoeba histolytic grown and maintained by serial subcultures in modified Boeck and Irabhlav’s medium, the effect of heat stress on the virulence of the amoeba and modifying effect thereon of cyproheptadine were examined. Weanling albino rats of Charles Foster strain were used as experimental animals and virulence was quantitated by the caecal score criteria on Neal. All the strains of E histotytica tested showed significantly higher virulence in animals subjected to heat stress, compared to those kept at ambient temperature. Although this enhanced virulence under heat stress could be lowered significantly by simultaneous administration of cyproheptadine, even then the caecal scores were higher than that in the controls. On the basis of the results it is postulated that 5-hydroxytrptamine plays an important role in enhancing the virulence of the hosts under heat stress.
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