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Year : 1986  |  Volume : 4  |  Issue : 3  |  Page : 153-161

Circulating Immune Complexes In Patients With Breast Cancer



Correspondence Address:
Poonam Katyal


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Circulating immune complexes (CIC) were determined in the sera of sixty-five patients with breast cancer and twenty-six normal healthy women matched for age and marital status by inhibition of rheumatoid factor (RF) mediated agglutination of IgG coated latex particles (LAI) polyethylene glycol precipitation (PEG-pptn.), and polyethylene glycol precipitation complement consumption (PEG-C’C) tests. The inhibitory activity was present in 73.8% of the sera from patients with breast cancer but none of the sera from control women contained this activity. Similarly, 24.6% and 35.4% of serum samples from cancer patients were positive for CIC by PEG-pptn. and PEG-C’C assay systems respectively, while only 7.7% of normal serum samples were positive by these two tests. No correlation was observed among these tests, which may be due to the difference in their ability to identify complexes of different sizes and molecular composition in addition to their sensitivity. A combination of all three tests determined CIC in 86.2% of patients, while a combination of PEG pptn. or PEG-C’C with LAI could detect complexes in 80% and 84.6% respectively. The significance of these findings is discussed.






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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04